TY - JOUR
T1 - Evolution and spatiotemporal dynamics of enterovirus A71 subgenogroups in Vietnam
AU - Thao, Nguyen Thi Thanh
AU - Donato, Celeste
AU - Trang, Vu Thi Huyen
AU - Kien, Nguyen Trung
AU - Trang, Pham Mai Thuy
AU - Khanh, Tran Quoc
AU - Nguyet, Dang Thi
AU - Sessions, October M.
AU - Cuong, Hoang Quoc
AU - Lan, Phan Trong
AU - Huong, Vu Thi Que
AU - Rogier Van Doorn, H.
AU - Vijaykrishna, Dhanasekaran
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background. Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and viral encephaliThis in children across the Asia-Pacifc region, including in Vietnam, which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5, and B5) concurrently circulate in the region with a large variation in epidemic severity. Te relative differences in their evolution and epidemiology were examined within Vietnam and globally. Methods. A total of 752 VP1 gene sequences were analyzed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003-2013, along with epidemiological metadata. Globally representative VP1 gene datasets of subgenogroups were used to coestimate time-resolved phylogenies and relative genetic diversity to infer virus origins and regional transmission network. Results. Despite frequent virus migration between countries, the highest genetic diversity of individual subgenogroups was maintained independently for several years in specifc Asian countries representing genogroup-specifc sources of EV-A71 diversity. Conclusion. This study highlights a persistent transmission network of EV-A71, with specifc Asian countries seeding other countries in the region and beyond, emphasizing the need for improved EV-A71 surveillance and detailed genetic and antigenic characterization.
AB - Background. Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and viral encephaliThis in children across the Asia-Pacifc region, including in Vietnam, which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5, and B5) concurrently circulate in the region with a large variation in epidemic severity. Te relative differences in their evolution and epidemiology were examined within Vietnam and globally. Methods. A total of 752 VP1 gene sequences were analyzed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003-2013, along with epidemiological metadata. Globally representative VP1 gene datasets of subgenogroups were used to coestimate time-resolved phylogenies and relative genetic diversity to infer virus origins and regional transmission network. Results. Despite frequent virus migration between countries, the highest genetic diversity of individual subgenogroups was maintained independently for several years in specifc Asian countries representing genogroup-specifc sources of EV-A71 diversity. Conclusion. This study highlights a persistent transmission network of EV-A71, with specifc Asian countries seeding other countries in the region and beyond, emphasizing the need for improved EV-A71 surveillance and detailed genetic and antigenic characterization.
KW - Enterovirus A71
KW - Hand foot and mouth disease
KW - Phylogenetics
KW - Vietnam
UR - http://www.scopus.com/inward/record.url?scp=85038641673&partnerID=8YFLogxK
U2 - 10.1093/infdis/jix500
DO - 10.1093/infdis/jix500
M3 - Article
C2 - 29029128
AN - SCOPUS:85038641673
VL - 216
SP - 1371
EP - 1379
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 11
ER -