TY - JOUR
T1 - Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD)
T2 - Analysis and pooled analysis
AU - Kent, L.
AU - Doerry, U.
AU - Hardy, E.
AU - Parmar, R.
AU - Gingell, K.
AU - Hawi, Z.
AU - Kirley, A.
AU - Lowe, N.
AU - Fitzgerald, M
AU - Gill, M.
AU - Craddock, N.
PY - 2002
Y1 - 2002
N2 - Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children. Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD. Consistent with these results we have also found a trend for the long allele of the promoter polymorphism to influence susceptibility to ADHD in a sample of 113 ADHD parent proband trios (65 transmissions vs 49 non-transmissions, χ2 = 2.25, P = 0.13). A pooled analysis of our, and these published results demonstrated a significant over representation of the long allele of the promoter in ADHD probands compared to controls (χ2 = 7.14, P = 0.008). We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3′ UTR SNP). TDT analysis demonstrated preferential transmission of the T allele of the 3′ UTR SNP (χ2 = 4.06, P = 0.04). In addition, ETDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3′ UTR SNP with the long allele of the promoter polymorphism (χ2 = 13.18, 3 df, P = 0.004) and the 10 repeat of the VNTR (χ2 = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.
AB - Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children. Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD. Consistent with these results we have also found a trend for the long allele of the promoter polymorphism to influence susceptibility to ADHD in a sample of 113 ADHD parent proband trios (65 transmissions vs 49 non-transmissions, χ2 = 2.25, P = 0.13). A pooled analysis of our, and these published results demonstrated a significant over representation of the long allele of the promoter in ADHD probands compared to controls (χ2 = 7.14, P = 0.008). We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3′ UTR SNP). TDT analysis demonstrated preferential transmission of the T allele of the 3′ UTR SNP (χ2 = 4.06, P = 0.04). In addition, ETDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3′ UTR SNP with the long allele of the promoter polymorphism (χ2 = 13.18, 3 df, P = 0.004) and the 10 repeat of the VNTR (χ2 = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.
KW - 5HTT
KW - ADHD
KW - Association study
KW - HSERT
UR - http://www.scopus.com/inward/record.url?scp=0036384203&partnerID=8YFLogxK
U2 - 10.1038/sj.mp.4001100
DO - 10.1038/sj.mp.4001100
M3 - Article
C2 - 12232786
AN - SCOPUS:0036384203
VL - 7
SP - 908
EP - 912
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
IS - 8
ER -