Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): Analysis and pooled analysis

L. Kent; U. Doerry; E. Hardy; R. Parmar; K. Gingell; Z. Hawi; A. Kirley; N. Lowe; M Fitzgerald; M. Gill; N. Craddock

doi:10.1038/sj.mp.4001100

Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD)

Analysis and pooled analysis

L. Kent, U. Doerry, E. Hardy, R. Parmar, K. Gingell, Z. Hawi, A. Kirley, N. Lowe, M Fitzgerald, M. Gill, N. Craddock

Research output: Contribution to journal › Article › Research › peer-review

124 Citations (Scopus)

Abstract

Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children. Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD. Consistent with these results we have also found a trend for the long allele of the promoter polymorphism to influence susceptibility to ADHD in a sample of 113 ADHD parent proband trios (65 transmissions vs 49 non-transmissions, χ2 = 2.25, P = 0.13). A pooled analysis of our, and these published results demonstrated a significant over representation of the long allele of the promoter in ADHD probands compared to controls (χ2 = 7.14, P = 0.008). We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3′ UTR SNP). TDT analysis demonstrated preferential transmission of the T allele of the 3′ UTR SNP (χ2 = 4.06, P = 0.04). In addition, ETDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3′ UTR SNP with the long allele of the promoter polymorphism (χ2 = 13.18, 3 df, P = 0.004) and the 10 repeat of the VNTR (χ2 = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.

Original language	English
Pages (from-to)	908-912
Number of pages	5
Journal	Molecular Psychiatry
Volume	7
Issue number	8
DOIs	https://doi.org/10.1038/sj.mp.4001100
Publication status	Published - 2002
Externally published	Yes

Keywords

5HTT
ADHD
Association study
HSERT

Cite this

Kent, L., Doerry, U., Hardy, E., Parmar, R., Gingell, K., Hawi, Z., ... Craddock, N. (2002). Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): Analysis and pooled analysis. Molecular Psychiatry, 7(8), 908-912. https://doi.org/10.1038/sj.mp.4001100

Kent, L. ; Doerry, U. ; Hardy, E. ; Parmar, R. ; Gingell, K. ; Hawi, Z. ; Kirley, A. ; Lowe, N. ; Fitzgerald, M ; Gill, M. ; Craddock, N. / Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD) : Analysis and pooled analysis. In: Molecular Psychiatry. 2002 ; Vol. 7, No. 8. pp. 908-912.

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abstract = "Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children. Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD. Consistent with these results we have also found a trend for the long allele of the promoter polymorphism to influence susceptibility to ADHD in a sample of 113 ADHD parent proband trios (65 transmissions vs 49 non-transmissions, χ2 = 2.25, P = 0.13). A pooled analysis of our, and these published results demonstrated a significant over representation of the long allele of the promoter in ADHD probands compared to controls (χ2 = 7.14, P = 0.008). We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3′ UTR SNP). TDT analysis demonstrated preferential transmission of the T allele of the 3′ UTR SNP (χ2 = 4.06, P = 0.04). In addition, ETDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3′ UTR SNP with the long allele of the promoter polymorphism (χ2 = 13.18, 3 df, P = 0.004) and the 10 repeat of the VNTR (χ2 = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.",

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Kent, L, Doerry, U, Hardy, E, Parmar, R, Gingell, K, Hawi, Z, Kirley, A, Lowe, N, Fitzgerald, M, Gill, M & Craddock, N 2002, 'Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): Analysis and pooled analysis', Molecular Psychiatry, vol. 7, no. 8, pp. 908-912. https://doi.org/10.1038/sj.mp.4001100

Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD) : Analysis and pooled analysis. / Kent, L.; Doerry, U.; Hardy, E.; Parmar, R.; Gingell, K.; Hawi, Z.; Kirley, A.; Lowe, N.; Fitzgerald, M; Gill, M.; Craddock, N.

In: Molecular Psychiatry, Vol. 7, No. 8, 2002, p. 908-912.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Doerry, U.

AU - Hardy, E.

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AU - Gingell, K.

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