Evidence of Microvascular Changes in the Retina following Kawasaki Disease

Katherine Y.H. Chen, David P. Burgner, Tien Yin Wong, Seang Mei Saw, Swee Chye Quek, Audrey Y.C. Pang, Seo Wei Leo, Inez B. Wong, Diana Zannino, Nigel Curtis, Michael M H Cheung, Carol Y. Cheung, Terence C.W. Lim

Research output: Contribution to journalArticleResearchpeer-review

Abstract

It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and is associated with traditional cardiovascular risk factors and events. The aim of this study was to investigate retinal microvascular parameters in two populations of patients with previous KD and control participants. We performed case-control studies of 116 (57 patients and 59 control participants) Australian and 156 (78 patients and 78 control participants) Singaporean individuals, at least two years since their acute illness. Standardised retinal photographs were graded by trained technicians using a semi-Automated software, which quantifies the retinal microvasculature (calibre, branching angle, fractal dimensions, and tortuosity). Retinal venules of Singaporean KD patients were 9.67 μm (95% CI 4.87 to 14.51, p < 0.001) larger than control participants following correction for traditional cardiovascular risk factors. An incremental increase in the size of retinal venules in those with coronary artery abnormalities was observed. There was limited evidence that retinal venules were larger in Australian KD patients with coronary artery abnormalities compared to control participants (7.34 μm, 95% CI 1.30 to 15.99, p = 0.10). Differences in retinal microvasculature were particularly evident in Singaporean KD patients. Larger retinal venules may reflect chronic inflammation and endothelial dysfunction, and are associated with coronary artery disease in adults.

Original languageEnglish
Article number40513
Number of pages8
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 17 Jan 2017

Cite this

Chen, K. Y. H., Burgner, D. P., Wong, T. Y., Saw, S. M., Quek, S. C., Pang, A. Y. C., ... Lim, T. C. W. (2017). Evidence of Microvascular Changes in the Retina following Kawasaki Disease. Scientific Reports, 7, [40513]. https://doi.org/10.1038/srep40513
Chen, Katherine Y.H. ; Burgner, David P. ; Wong, Tien Yin ; Saw, Seang Mei ; Quek, Swee Chye ; Pang, Audrey Y.C. ; Leo, Seo Wei ; Wong, Inez B. ; Zannino, Diana ; Curtis, Nigel ; Cheung, Michael M H ; Cheung, Carol Y. ; Lim, Terence C.W. / Evidence of Microvascular Changes in the Retina following Kawasaki Disease. In: Scientific Reports. 2017 ; Vol. 7.
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abstract = "It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and is associated with traditional cardiovascular risk factors and events. The aim of this study was to investigate retinal microvascular parameters in two populations of patients with previous KD and control participants. We performed case-control studies of 116 (57 patients and 59 control participants) Australian and 156 (78 patients and 78 control participants) Singaporean individuals, at least two years since their acute illness. Standardised retinal photographs were graded by trained technicians using a semi-Automated software, which quantifies the retinal microvasculature (calibre, branching angle, fractal dimensions, and tortuosity). Retinal venules of Singaporean KD patients were 9.67 μm (95{\%} CI 4.87 to 14.51, p < 0.001) larger than control participants following correction for traditional cardiovascular risk factors. An incremental increase in the size of retinal venules in those with coronary artery abnormalities was observed. There was limited evidence that retinal venules were larger in Australian KD patients with coronary artery abnormalities compared to control participants (7.34 μm, 95{\%} CI 1.30 to 15.99, p = 0.10). Differences in retinal microvasculature were particularly evident in Singaporean KD patients. Larger retinal venules may reflect chronic inflammation and endothelial dysfunction, and are associated with coronary artery disease in adults.",
author = "Chen, {Katherine Y.H.} and Burgner, {David P.} and Wong, {Tien Yin} and Saw, {Seang Mei} and Quek, {Swee Chye} and Pang, {Audrey Y.C.} and Leo, {Seo Wei} and Wong, {Inez B.} and Diana Zannino and Nigel Curtis and Cheung, {Michael M H} and Cheung, {Carol Y.} and Lim, {Terence C.W.}",
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Chen, KYH, Burgner, DP, Wong, TY, Saw, SM, Quek, SC, Pang, AYC, Leo, SW, Wong, IB, Zannino, D, Curtis, N, Cheung, MMH, Cheung, CY & Lim, TCW 2017, 'Evidence of Microvascular Changes in the Retina following Kawasaki Disease' Scientific Reports, vol. 7, 40513. https://doi.org/10.1038/srep40513

Evidence of Microvascular Changes in the Retina following Kawasaki Disease. / Chen, Katherine Y.H.; Burgner, David P.; Wong, Tien Yin; Saw, Seang Mei; Quek, Swee Chye; Pang, Audrey Y.C.; Leo, Seo Wei; Wong, Inez B.; Zannino, Diana; Curtis, Nigel; Cheung, Michael M H; Cheung, Carol Y.; Lim, Terence C.W.

In: Scientific Reports, Vol. 7, 40513, 17.01.2017.

Research output: Contribution to journalArticleResearchpeer-review

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