Evidence for the toxicity of bidirectional transcripts and mitochondrial dysfunction in blood associated with small CGG expansions in the FMR1 gene in patients with parkinsonism

Danuta Loesch, David Godler, Andrew Evans, Quang Bui, Freya Gehling, Katya Kotschet, Nicholas Trost, Elsdon Storey, Paige Stimpson, Glynda Kinsella, David Francis, David Thorburn, Alison Venn, Howard Slater, Malcolm Horne

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53 Citations (Scopus)

Abstract

Our previous results showed that both gray zone and lower end premutation range (40-85 repeats) fragile X mental retardation 1 (FMR1) alleles were more common among males with parkinsonism than in the general population. This study aimed to determine whether these alleles have a significant role in the manifestations and pathogenesis of parkinsonian disorders.
Original languageEnglish
Pages (from-to)392 - 399
Number of pages8
JournalGenetics in Medicine
Volume13
Issue number5
DOIs
Publication statusPublished - 2011

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