Evidence for the recruitment of autophagic vesicles in human brain after stroke

Tony Frugier; Juliet M. Taylor; Catriona McLean; Nicole Bye; Philip M. Beart; Rodney J. Devenish; Peter J. Crack

doi:10.1016/j.neuint.2016.02.016

Evidence for the recruitment of autophagic vesicles in human brain after stroke

Tony Frugier
, Juliet M. Taylor
, Catriona McLean
, Nicole Bye
, Philip M. Beart
, Rodney J. Devenish
, Peter J. Crack

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.

Original language	English
Pages (from-to)	62-68
Number of pages	7
Journal	Neurochemistry International
Volume	96
DOIs	https://doi.org/10.1016/j.neuint.2016.02.016
Publication status	Published - Jun 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

autophagy
stroke
human
brain
LC3
P62

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10.1016/j.neuint.2016.02.016

Cite this

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title = "Evidence for the recruitment of autophagic vesicles in human brain after stroke",

abstract = "Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.",

keywords = "autophagy, stroke, human, brain, LC3, P62",

author = "Tony Frugier and Taylor, \{Juliet M.\} and Catriona McLean and Nicole Bye and Beart, \{Philip M.\} and Devenish, \{Rodney J.\} and Crack, \{Peter J.\}",

year = "2016",

month = jun,

doi = "10.1016/j.neuint.2016.02.016",

language = "English",

volume = "96",

pages = "62--68",

journal = "Neurochemistry International",

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T1 - Evidence for the recruitment of autophagic vesicles in human brain after stroke

AU - Frugier, Tony

AU - Taylor, Juliet M.

AU - McLean, Catriona

AU - Bye, Nicole

AU - Beart, Philip M.

AU - Devenish, Rodney J.

AU - Crack, Peter J.

PY - 2016/6

Y1 - 2016/6

N2 - Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.

AB - Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.

KW - autophagy

KW - stroke

KW - human

KW - brain

KW - LC3

KW - P62

UR - http://www.ncbi.nlm.nih.gov/pubmed/26930584

U2 - 10.1016/j.neuint.2016.02.016

DO - 10.1016/j.neuint.2016.02.016

M3 - Article

SN - 0197-0186

VL - 96

SP - 62

EP - 68

JO - Neurochemistry International

JF - Neurochemistry International

ER -

Evidence for the recruitment of autophagic vesicles in human brain after stroke

Abstract

UN SDGs

Keywords

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