Evidence for the recruitment of autophagic vesicles in human brain after stroke

Tony Frugier, Juliet M. Taylor, Catriona McLean, Nicole Bye, Philip M. Beart, Rodney J. Devenish, Peter J. Crack

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.
Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalNeurochemistry International
Volume96
DOIs
Publication statusPublished - Jun 2016

Keywords

  • autophagy
  • stroke
  • human
  • brain
  • LC3
  • P62

Cite this

Frugier, Tony ; Taylor, Juliet M. ; McLean, Catriona ; Bye, Nicole ; Beart, Philip M. ; Devenish, Rodney J. ; Crack, Peter J. / Evidence for the recruitment of autophagic vesicles in human brain after stroke. In: Neurochemistry International. 2016 ; Vol. 96. pp. 62-68.
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Evidence for the recruitment of autophagic vesicles in human brain after stroke. / Frugier, Tony; Taylor, Juliet M.; McLean, Catriona; Bye, Nicole; Beart, Philip M.; Devenish, Rodney J.; Crack, Peter J.

In: Neurochemistry International, Vol. 96, 06.2016, p. 62-68.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Frugier, Tony

AU - Taylor, Juliet M.

AU - McLean, Catriona

AU - Bye, Nicole

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AU - Devenish, Rodney J.

AU - Crack, Peter J.

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AB - Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.

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KW - stroke

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