Evening types demonstrate reduced SSRI treatment efficacy

E. M. McGlashan, S. P. A. Drummond, S. W. Cain

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)


Selective serotonin reuptake inhibitors (SSRIs) have a profound effect on the circadian system's response to environmental light, which may impact treatment outcomes for patients depending on their habitual light exposure patterns. Here, we investigated the relationship between time-of-day preference, depressive symptoms and self-reported antidepressant treatment response. Evening types reported having taken a higher number of antidepressant medications in the previous 5 years and lower SSRI efficacy than morning types. While undergoing SSRI treatment, evening types also reported more depressive symptoms and suicidality. It is concluded that time-of-day preference may prove informative in predicting SSRI treatment responses.

Original languageEnglish
Pages (from-to)1175-1178
Number of pages4
JournalChronobiology International
Issue number8
Publication statusPublished - 16 Apr 2018


  • Antidepressants
  • Chronotype
  • Circadian rhythms
  • Depression
  • Mood

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