Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines

Ram Prasad Bhusal, James R.O. Eaton, Sayeeda T. Chowdhury, Christine A. Power, Amanda E.I. Proudfoot, Martin J. Stone, Shoumo Bhattacharya

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Ticks are hematophagous arachnids that parasitize mammals and other hosts, feeding on their blood. Ticks secrete numerous salivary factors that enhance host blood flow or suppress the host inflammatory response. The recruitment of leukocytes, a hallmark of inflammation, is regulated by chemokines, which activate chemokine receptors on the leukocytes. Ticks target this process by secreting glycoproteins called Evasins, which bind to chemokines and prevent leukocyte recruitment. This review describes the recent discovery of numerous Evasins produced by ticks, their classification into two structural and functional classes, and the efficacy of Evasins in animal models of inflammatory diseases. The review also proposes a standard nomenclature system for Evasins and discusses the potential of repurposing or engineering Evasins as therapeutic anti-inflammatory agents.

Original languageEnglish
Pages (from-to)108-122
Number of pages15
JournalTrends in Biochemical Sciences
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • anti-inflammatory
  • binding protein
  • chemokine
  • Evasin
  • protein family

Cite this

Bhusal, R. P., Eaton, J. R. O., Chowdhury, S. T., Power, C. A., Proudfoot, A. E. I., Stone, M. J., & Bhattacharya, S. (2020). Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines. Trends in Biochemical Sciences, 45(2), 108-122. https://doi.org/10.1016/j.tibs.2019.10.003