Evaluation of some cyclic dipeptides as catalysts for the asymmetric hydrocyanation of aldehydes

W. Roy Jackson, Gamini S. Jayatilake, Barry R. Matthews, Colin Wilshire

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Abstract

A series of cyclic dipeptides has been prepared and evaluated as catalysts for the asymmetric hydrocyanation of benzaldehyde and 3-phenoxybenzaldehyde. Cyclo-(R, R)- or (S, S)-(phenylalanylhistidyl), previously reported by Inoue and his coworkers, has proven to be the most effective catalyst, giving high preparative and optical yields under appropriate conditions.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalAustralian Journal of Chemistry
Volume41
Issue number2
DOIs
Publication statusPublished - 1 Jan 1988

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