Evaluation of relaxin's antifibrotic action by SELDI-TOF mass spectrometry-based profiling of relaxin knockout mice, a model of progressive fibrosis

Eleni Giannakis, Mary Macris, Linda Chan, Geoffrey W Tregear, Chrishan S. Samuel, John D. Wade

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Abstract

Surface-enhanced laser desorption ionization-time-of-flight mass spectrometry was employed to identify potential biomarkers for early-onset fibrosis. These biomarkers were then used to evaluate the efficacy of relaxin to reverse or ameliorate the development of the condition.

Original languageEnglish
Title of host publicationRelaxin and Related Peptides Fifth International Conference
Pages350-352
Number of pages3
Volume1160
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1160
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Fibrosis
  • Protein profiling
  • Relaxin knockout mice
  • SELDI-TOF mass spectrometry

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