Evaluation of relaxin's antifibrotic action by SELDI-TOF mass spectrometry-based profiling of relaxin knockout mice, a model of progressive fibrosis

Eleni Giannakis, Mary Macris, Linda Chan, Geoffrey W Tregear, Chrishan S. Samuel, John D. Wade

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review


Surface-enhanced laser desorption ionization-time-of-flight mass spectrometry was employed to identify potential biomarkers for early-onset fibrosis. These biomarkers were then used to evaluate the efficacy of relaxin to reverse or ameliorate the development of the condition.

Original languageEnglish
Title of host publicationRelaxin and Related Peptides Fifth International Conference
Number of pages3
Publication statusPublished - Apr 2009
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Fibrosis
  • Protein profiling
  • Relaxin knockout mice
  • SELDI-TOF mass spectrometry

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