TY - JOUR
T1 - Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment
AU - Morise, Beatriz Tiemi
AU - Mutch, Alexandra Louise
AU - Garms, Bruna Cambraia
AU - Herculano, Rondinelli Donizetti
AU - Grøndahl, Lisbeth
N1 - Funding Information:
The authors would like to thank The São Paulo Research Foundation (FAPESP Processes 19/01650-5, 17/22686-2, and 14/17526-8) for financial support. Katarzyna Kępa is acknowledged for assistance with contact angle measurements. The author Alexandra Louise Mutch acknowledes Australian Government RTP scholarship Funding and author Bruna Cambraia Garms acknowledges a UQ Research Training Scholarship. The authors acknowledge the facilities, and the scientific and technical assistance of the Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy and Microanalysis (CMM), UQ.
Funding Information:
The authors would like to thank The São Paulo Research Foundation (FAPESP Processes 19/01650‐5, 17/22686‐2, and 14/17526‐8) for financial support. Katarzyna Kępa is acknowledged for assistance with contact angle measurements. The author Alexandra Louise Mutch acknowledes Australian Government RTP scholarship Funding and author Bruna Cambraia Garms acknowledges a UQ Research Training Scholarship. The authors acknowledge the facilities, and the scientific and technical assistance of the Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy and Microanalysis (CMM), UQ.
Publisher Copyright:
© 2020 Wiley Periodicals LLC.
PY - 2021/4/5
Y1 - 2021/4/5
N2 - Sialorrhea is a disorder which causes an increase in salivation. Scopolamine butylbromide (SBB) can be administrated to treat sialorrhea and its transdermal application minimizes the occurrence of side effects. This work compared SBB adsorption and release from two polymer matrices, polycaprolactone and natural rubber latex, as well as the matrices modified by gamma irradiation-induced graft copolymerization of acrylic acid (AAc). Grafting with AAc-introduced carboxylate groups onto the surface of the matrices evident from chemical analysis and resulted in increased hydrophilicity evident from contact angle measurements. SBB adsorbed to the matrices without changing its structure and for the AAc-grafted matrices this was governed by electrostatic interactions. Higher SBB loading was observed for the AAc-grafted matrices while SBB release was slower for the non-grafted matrices than the grafted matrices. The four different matrices produced are candidates for the development of a transdermal drug delivery system.
AB - Sialorrhea is a disorder which causes an increase in salivation. Scopolamine butylbromide (SBB) can be administrated to treat sialorrhea and its transdermal application minimizes the occurrence of side effects. This work compared SBB adsorption and release from two polymer matrices, polycaprolactone and natural rubber latex, as well as the matrices modified by gamma irradiation-induced graft copolymerization of acrylic acid (AAc). Grafting with AAc-introduced carboxylate groups onto the surface of the matrices evident from chemical analysis and resulted in increased hydrophilicity evident from contact angle measurements. SBB adsorbed to the matrices without changing its structure and for the AAc-grafted matrices this was governed by electrostatic interactions. Higher SBB loading was observed for the AAc-grafted matrices while SBB release was slower for the non-grafted matrices than the grafted matrices. The four different matrices produced are candidates for the development of a transdermal drug delivery system.
UR - http://www.scopus.com/inward/record.url?scp=85094652163&partnerID=8YFLogxK
U2 - 10.1002/app.50117
DO - 10.1002/app.50117
M3 - Article
AN - SCOPUS:85094652163
SN - 0021-8995
VL - 138
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 13
M1 - 50117
ER -