Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial

Roseanne Peel, Shu Ren, Alexis Hure, Tiffany Jane Evans, Catherine A. D'Este, Walter P. Abhayaratna, Andrew M. Tonkin, Ingrid Hopper, Amanda G. Thrift, Christopher R. Levi, Jonathan Sturm, David Durrheim, Joseph Hung, Tom G. Briffa, Derek P. Chew, Phil Anderson, Lynelle Moon, Mark McEvoy, Philip M. Hansbro, David A. Newby & 1 others John R. Attia

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Objectives: To examine the effectiveness of different strategies for recruiting participants for a large Australian randomised controlled trial (RCT), the Australian Study for the Prevention through Immunisation of Cardiovascular Events (AUSPICE). Design, setting, participants: Men and women aged 55–60 years with at least two cardiovascular risk factors (hypertension, hypercholesterolaemia, overweight/obesity) were recruited for a multicentre placebo-controlled RCT assessing the effectiveness of 23-valent pneumococcal polysaccharide vaccine (23vPPV) for preventing cardiovascular events. Methods: Invitations were mailed by the Australian Department of Human Services to people in the Medicare database aged 55–60 years; reminders were sent 2 weeks later. Invitees could respond in hard copy or electronically. Direct recruitment was supplemented by asking invitees to extend the invitation to friends and family (snowball sampling) and by Facebook advertising. Main outcome: Proportions of invitees completing screening questionnaire and recruited for participation in the RCT. Results: 21 526 of 154 992 invited people (14%) responded by completing the screening questionnaire, of whom 4725 people were eligible and recruited for the study. Despite the minimal study burden (one questionnaire, one clinic visit), the overall participation rate was 3%, or an estimated 10% of eligible persons. Only 16% of eventual participants had responded within 2 weeks of the initial invitation letter (early responders); early and late responders did not differ in their demographic or medical characteristics. Socio-economic disadvantage did not markedly influence response rates. Facebook advertising and snowball sampling did not increase recruitment. Conclusions: Trial participation rates are low, and multiple concurrent methods are needed to maximise recruitment. Social media strategies may not be successful in older age groups. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12615000536561.

Original languageEnglish
Pages (from-to)409-415
Number of pages7
JournalMedical Journal of Australia
Volume210
Issue number9
DOIs
Publication statusPublished - May 2019

Keywords

  • Clinical trials as topic
  • Public health
  • Randomized controlled trial as topic
  • Social media
  • Vaccine preventable disease
  • Vaccines

Cite this

Peel, Roseanne ; Ren, Shu ; Hure, Alexis ; Evans, Tiffany Jane ; D'Este, Catherine A. ; Abhayaratna, Walter P. ; Tonkin, Andrew M. ; Hopper, Ingrid ; Thrift, Amanda G. ; Levi, Christopher R. ; Sturm, Jonathan ; Durrheim, David ; Hung, Joseph ; Briffa, Tom G. ; Chew, Derek P. ; Anderson, Phil ; Moon, Lynelle ; McEvoy, Mark ; Hansbro, Philip M. ; Newby, David A. ; Attia, John R. / Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial. In: Medical Journal of Australia. 2019 ; Vol. 210, No. 9. pp. 409-415.
@article{b994904726e04df896c1b82218968edc,
title = "Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial",
abstract = "Objectives: To examine the effectiveness of different strategies for recruiting participants for a large Australian randomised controlled trial (RCT), the Australian Study for the Prevention through Immunisation of Cardiovascular Events (AUSPICE). Design, setting, participants: Men and women aged 55–60 years with at least two cardiovascular risk factors (hypertension, hypercholesterolaemia, overweight/obesity) were recruited for a multicentre placebo-controlled RCT assessing the effectiveness of 23-valent pneumococcal polysaccharide vaccine (23vPPV) for preventing cardiovascular events. Methods: Invitations were mailed by the Australian Department of Human Services to people in the Medicare database aged 55–60 years; reminders were sent 2 weeks later. Invitees could respond in hard copy or electronically. Direct recruitment was supplemented by asking invitees to extend the invitation to friends and family (snowball sampling) and by Facebook advertising. Main outcome: Proportions of invitees completing screening questionnaire and recruited for participation in the RCT. Results: 21 526 of 154 992 invited people (14{\%}) responded by completing the screening questionnaire, of whom 4725 people were eligible and recruited for the study. Despite the minimal study burden (one questionnaire, one clinic visit), the overall participation rate was 3{\%}, or an estimated 10{\%} of eligible persons. Only 16{\%} of eventual participants had responded within 2 weeks of the initial invitation letter (early responders); early and late responders did not differ in their demographic or medical characteristics. Socio-economic disadvantage did not markedly influence response rates. Facebook advertising and snowball sampling did not increase recruitment. Conclusions: Trial participation rates are low, and multiple concurrent methods are needed to maximise recruitment. Social media strategies may not be successful in older age groups. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12615000536561.",
keywords = "Clinical trials as topic, Public health, Randomized controlled trial as topic, Social media, Vaccine preventable disease, Vaccines",
author = "Roseanne Peel and Shu Ren and Alexis Hure and Evans, {Tiffany Jane} and D'Este, {Catherine A.} and Abhayaratna, {Walter P.} and Tonkin, {Andrew M.} and Ingrid Hopper and Thrift, {Amanda G.} and Levi, {Christopher R.} and Jonathan Sturm and David Durrheim and Joseph Hung and Briffa, {Tom G.} and Chew, {Derek P.} and Phil Anderson and Lynelle Moon and Mark McEvoy and Hansbro, {Philip M.} and Newby, {David A.} and Attia, {John R.}",
year = "2019",
month = "5",
doi = "10.5694/mja2.50117",
language = "English",
volume = "210",
pages = "409--415",
journal = "Medical Journal of Australia",
issn = "0025-729X",
publisher = "AMPCo",
number = "9",

}

Peel, R, Ren, S, Hure, A, Evans, TJ, D'Este, CA, Abhayaratna, WP, Tonkin, AM, Hopper, I, Thrift, AG, Levi, CR, Sturm, J, Durrheim, D, Hung, J, Briffa, TG, Chew, DP, Anderson, P, Moon, L, McEvoy, M, Hansbro, PM, Newby, DA & Attia, JR 2019, 'Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial', Medical Journal of Australia, vol. 210, no. 9, pp. 409-415. https://doi.org/10.5694/mja2.50117

Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial. / Peel, Roseanne; Ren, Shu; Hure, Alexis; Evans, Tiffany Jane; D'Este, Catherine A.; Abhayaratna, Walter P.; Tonkin, Andrew M.; Hopper, Ingrid; Thrift, Amanda G.; Levi, Christopher R.; Sturm, Jonathan; Durrheim, David; Hung, Joseph; Briffa, Tom G.; Chew, Derek P.; Anderson, Phil; Moon, Lynelle; McEvoy, Mark; Hansbro, Philip M.; Newby, David A.; Attia, John R.

In: Medical Journal of Australia, Vol. 210, No. 9, 05.2019, p. 409-415.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial

AU - Peel, Roseanne

AU - Ren, Shu

AU - Hure, Alexis

AU - Evans, Tiffany Jane

AU - D'Este, Catherine A.

AU - Abhayaratna, Walter P.

AU - Tonkin, Andrew M.

AU - Hopper, Ingrid

AU - Thrift, Amanda G.

AU - Levi, Christopher R.

AU - Sturm, Jonathan

AU - Durrheim, David

AU - Hung, Joseph

AU - Briffa, Tom G.

AU - Chew, Derek P.

AU - Anderson, Phil

AU - Moon, Lynelle

AU - McEvoy, Mark

AU - Hansbro, Philip M.

AU - Newby, David A.

AU - Attia, John R.

PY - 2019/5

Y1 - 2019/5

N2 - Objectives: To examine the effectiveness of different strategies for recruiting participants for a large Australian randomised controlled trial (RCT), the Australian Study for the Prevention through Immunisation of Cardiovascular Events (AUSPICE). Design, setting, participants: Men and women aged 55–60 years with at least two cardiovascular risk factors (hypertension, hypercholesterolaemia, overweight/obesity) were recruited for a multicentre placebo-controlled RCT assessing the effectiveness of 23-valent pneumococcal polysaccharide vaccine (23vPPV) for preventing cardiovascular events. Methods: Invitations were mailed by the Australian Department of Human Services to people in the Medicare database aged 55–60 years; reminders were sent 2 weeks later. Invitees could respond in hard copy or electronically. Direct recruitment was supplemented by asking invitees to extend the invitation to friends and family (snowball sampling) and by Facebook advertising. Main outcome: Proportions of invitees completing screening questionnaire and recruited for participation in the RCT. Results: 21 526 of 154 992 invited people (14%) responded by completing the screening questionnaire, of whom 4725 people were eligible and recruited for the study. Despite the minimal study burden (one questionnaire, one clinic visit), the overall participation rate was 3%, or an estimated 10% of eligible persons. Only 16% of eventual participants had responded within 2 weeks of the initial invitation letter (early responders); early and late responders did not differ in their demographic or medical characteristics. Socio-economic disadvantage did not markedly influence response rates. Facebook advertising and snowball sampling did not increase recruitment. Conclusions: Trial participation rates are low, and multiple concurrent methods are needed to maximise recruitment. Social media strategies may not be successful in older age groups. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12615000536561.

AB - Objectives: To examine the effectiveness of different strategies for recruiting participants for a large Australian randomised controlled trial (RCT), the Australian Study for the Prevention through Immunisation of Cardiovascular Events (AUSPICE). Design, setting, participants: Men and women aged 55–60 years with at least two cardiovascular risk factors (hypertension, hypercholesterolaemia, overweight/obesity) were recruited for a multicentre placebo-controlled RCT assessing the effectiveness of 23-valent pneumococcal polysaccharide vaccine (23vPPV) for preventing cardiovascular events. Methods: Invitations were mailed by the Australian Department of Human Services to people in the Medicare database aged 55–60 years; reminders were sent 2 weeks later. Invitees could respond in hard copy or electronically. Direct recruitment was supplemented by asking invitees to extend the invitation to friends and family (snowball sampling) and by Facebook advertising. Main outcome: Proportions of invitees completing screening questionnaire and recruited for participation in the RCT. Results: 21 526 of 154 992 invited people (14%) responded by completing the screening questionnaire, of whom 4725 people were eligible and recruited for the study. Despite the minimal study burden (one questionnaire, one clinic visit), the overall participation rate was 3%, or an estimated 10% of eligible persons. Only 16% of eventual participants had responded within 2 weeks of the initial invitation letter (early responders); early and late responders did not differ in their demographic or medical characteristics. Socio-economic disadvantage did not markedly influence response rates. Facebook advertising and snowball sampling did not increase recruitment. Conclusions: Trial participation rates are low, and multiple concurrent methods are needed to maximise recruitment. Social media strategies may not be successful in older age groups. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12615000536561.

KW - Clinical trials as topic

KW - Public health

KW - Randomized controlled trial as topic

KW - Social media

KW - Vaccine preventable disease

KW - Vaccines

UR - http://www.scopus.com/inward/record.url?scp=85063394750&partnerID=8YFLogxK

U2 - 10.5694/mja2.50117

DO - 10.5694/mja2.50117

M3 - Article

VL - 210

SP - 409

EP - 415

JO - Medical Journal of Australia

JF - Medical Journal of Australia

SN - 0025-729X

IS - 9

ER -