European Multicentre Association Study of Schizophrenia

A study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms

G. Spurlock, J. Williams, P. McGuffin, H. N. Aschauer, E. Lenzinger, K. Fuchs, W. C. Sieghart, K. Meszaros, N. Fathi, C. Laurent, J. Mallet, F. Macciardi, S. Pedrini, M. Gill, Z. Hawi, S. Gibson, E. E. Jazin, Hai Tao Yang, R. Adolfsson, C. N. Pato & 2 others A. M. Dourado, M. J. Owen

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Abstract

As part of the European Multicentre Association Study of Schizophrenia (EMASS), we studied polymorphisms in the dopamine DRD2 and DRD3 receptor genes. The EMASS collaboration was established to create a large, statistically powerful sample of schizophrenic patients and controls from different European centres. Previous studies have suggested associations between schizophrenia and the Ser311Cys polymorphism in exon 7 of the dopamine DRD2 receptor gene [Arinami et al., (1994): Lancet 343:703-704] and a polymorphism Ser9gly in exon 1 of the dopamine DRD3 receptor gene [Crocq et al. (1992): J Med Genet 29:858-860]. We tested for these associations in samples of 373 and 413, and 311 and 306 patients and controls, respectively. We found no evidence for allelic association between schizophrenia and the Cys311 variant of the DRD2 receptor gene and no homozygotes for this variant were observed by any group. However, an excess of homozygotes for both alleles of the DRD3 polymorphism was observed in schizophrenic patients (χ2 = 8.54, P = 0.003, odds ratio = 1.64, 95% CI = 1.18-2.29). We also observed a significant excess of the 1-1 (Ser9Ser) genotype (χ2 = 8.13, P = 0.004, odds ratio = 1.7, 95% CI = 1.18-2.4). No evidence of heterogeneity between samples was detected and there was no evidence of an allelic association. These findings suggest that the rare Cys311 variant in exon 7 of the DRD2 receptor gene does not play a role in the pathogenesis of schizophrenia in European populations. Currently, our results do support the previous findings of an association between increased homozygosity of the Ser/Gly variant of the Dopamine D3 receptor gene and schizophrenia.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume81
Issue number1
DOIs
Publication statusPublished - 7 Feb 1998
Externally publishedYes

Keywords

  • Association
  • Dopamine DRD2
  • Dopamine DRD3
  • Schizophrenia

Cite this

Spurlock, G. ; Williams, J. ; McGuffin, P. ; Aschauer, H. N. ; Lenzinger, E. ; Fuchs, K. ; Sieghart, W. C. ; Meszaros, K. ; Fathi, N. ; Laurent, C. ; Mallet, J. ; Macciardi, F. ; Pedrini, S. ; Gill, M. ; Hawi, Z. ; Gibson, S. ; Jazin, E. E. ; Yang, Hai Tao ; Adolfsson, R. ; Pato, C. N. ; Dourado, A. M. ; Owen, M. J. / European Multicentre Association Study of Schizophrenia : A study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 1998 ; Vol. 81, No. 1. pp. 24-28.
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title = "European Multicentre Association Study of Schizophrenia: A study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms",
abstract = "As part of the European Multicentre Association Study of Schizophrenia (EMASS), we studied polymorphisms in the dopamine DRD2 and DRD3 receptor genes. The EMASS collaboration was established to create a large, statistically powerful sample of schizophrenic patients and controls from different European centres. Previous studies have suggested associations between schizophrenia and the Ser311Cys polymorphism in exon 7 of the dopamine DRD2 receptor gene [Arinami et al., (1994): Lancet 343:703-704] and a polymorphism Ser9gly in exon 1 of the dopamine DRD3 receptor gene [Crocq et al. (1992): J Med Genet 29:858-860]. We tested for these associations in samples of 373 and 413, and 311 and 306 patients and controls, respectively. We found no evidence for allelic association between schizophrenia and the Cys311 variant of the DRD2 receptor gene and no homozygotes for this variant were observed by any group. However, an excess of homozygotes for both alleles of the DRD3 polymorphism was observed in schizophrenic patients (χ2 = 8.54, P = 0.003, odds ratio = 1.64, 95{\%} CI = 1.18-2.29). We also observed a significant excess of the 1-1 (Ser9Ser) genotype (χ2 = 8.13, P = 0.004, odds ratio = 1.7, 95{\%} CI = 1.18-2.4). No evidence of heterogeneity between samples was detected and there was no evidence of an allelic association. These findings suggest that the rare Cys311 variant in exon 7 of the DRD2 receptor gene does not play a role in the pathogenesis of schizophrenia in European populations. Currently, our results do support the previous findings of an association between increased homozygosity of the Ser/Gly variant of the Dopamine D3 receptor gene and schizophrenia.",
keywords = "Association, Dopamine DRD2, Dopamine DRD3, Schizophrenia",
author = "G. Spurlock and J. Williams and P. McGuffin and Aschauer, {H. N.} and E. Lenzinger and K. Fuchs and Sieghart, {W. C.} and K. Meszaros and N. Fathi and C. Laurent and J. Mallet and F. Macciardi and S. Pedrini and M. Gill and Z. Hawi and S. Gibson and Jazin, {E. E.} and Yang, {Hai Tao} and R. Adolfsson and Pato, {C. N.} and Dourado, {A. M.} and Owen, {M. J.}",
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Spurlock, G, Williams, J, McGuffin, P, Aschauer, HN, Lenzinger, E, Fuchs, K, Sieghart, WC, Meszaros, K, Fathi, N, Laurent, C, Mallet, J, Macciardi, F, Pedrini, S, Gill, M, Hawi, Z, Gibson, S, Jazin, EE, Yang, HT, Adolfsson, R, Pato, CN, Dourado, AM & Owen, MJ 1998, 'European Multicentre Association Study of Schizophrenia: A study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 81, no. 1, pp. 24-28. https://doi.org/10.1002/(SICI)1096-8628(19980207)81:1<24::AID-AJMG5>3.0.CO;2-N

European Multicentre Association Study of Schizophrenia : A study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms. / Spurlock, G.; Williams, J.; McGuffin, P.; Aschauer, H. N.; Lenzinger, E.; Fuchs, K.; Sieghart, W. C.; Meszaros, K.; Fathi, N.; Laurent, C.; Mallet, J.; Macciardi, F.; Pedrini, S.; Gill, M.; Hawi, Z.; Gibson, S.; Jazin, E. E.; Yang, Hai Tao; Adolfsson, R.; Pato, C. N.; Dourado, A. M.; Owen, M. J.

In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 81, No. 1, 07.02.1998, p. 24-28.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - European Multicentre Association Study of Schizophrenia

T2 - A study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms

AU - Spurlock, G.

AU - Williams, J.

AU - McGuffin, P.

AU - Aschauer, H. N.

AU - Lenzinger, E.

AU - Fuchs, K.

AU - Sieghart, W. C.

AU - Meszaros, K.

AU - Fathi, N.

AU - Laurent, C.

AU - Mallet, J.

AU - Macciardi, F.

AU - Pedrini, S.

AU - Gill, M.

AU - Hawi, Z.

AU - Gibson, S.

AU - Jazin, E. E.

AU - Yang, Hai Tao

AU - Adolfsson, R.

AU - Pato, C. N.

AU - Dourado, A. M.

AU - Owen, M. J.

PY - 1998/2/7

Y1 - 1998/2/7

N2 - As part of the European Multicentre Association Study of Schizophrenia (EMASS), we studied polymorphisms in the dopamine DRD2 and DRD3 receptor genes. The EMASS collaboration was established to create a large, statistically powerful sample of schizophrenic patients and controls from different European centres. Previous studies have suggested associations between schizophrenia and the Ser311Cys polymorphism in exon 7 of the dopamine DRD2 receptor gene [Arinami et al., (1994): Lancet 343:703-704] and a polymorphism Ser9gly in exon 1 of the dopamine DRD3 receptor gene [Crocq et al. (1992): J Med Genet 29:858-860]. We tested for these associations in samples of 373 and 413, and 311 and 306 patients and controls, respectively. We found no evidence for allelic association between schizophrenia and the Cys311 variant of the DRD2 receptor gene and no homozygotes for this variant were observed by any group. However, an excess of homozygotes for both alleles of the DRD3 polymorphism was observed in schizophrenic patients (χ2 = 8.54, P = 0.003, odds ratio = 1.64, 95% CI = 1.18-2.29). We also observed a significant excess of the 1-1 (Ser9Ser) genotype (χ2 = 8.13, P = 0.004, odds ratio = 1.7, 95% CI = 1.18-2.4). No evidence of heterogeneity between samples was detected and there was no evidence of an allelic association. These findings suggest that the rare Cys311 variant in exon 7 of the DRD2 receptor gene does not play a role in the pathogenesis of schizophrenia in European populations. Currently, our results do support the previous findings of an association between increased homozygosity of the Ser/Gly variant of the Dopamine D3 receptor gene and schizophrenia.

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