Eurifoloids A-R, structurally diverse diterpenoids from Euphorbia neriifolia

Jin Xin Zhao; Cui Ping Liu; Wei Yan Qi; Mei Ling Han; Ying Shan Han; Mark A. Wainberg; Jian Min Yue

doi:10.1021/np5004752

Eurifoloids A-R, structurally diverse diterpenoids from Euphorbia neriifolia

Jin Xin Zhao
, Cui Ping Liu
, Wei Yan Qi
, Mei Ling Han
, Ying Shan Han
, Mark A. Wainberg
, Jian Min Yue

Research output: Contribution to journal › Article › Research › peer-review

76 Citations (Scopus)

Abstract

Eighteen new diterpenoids, named eurifoloids A-R (1-18), including ingenane (1 and 2), abietane (3-7), isopimarane (8-12), and ent-atisane (13-18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC₅₀ values of 3.58 ± 0.31 (SI = 8.6) and 7.40 ± 0.94 M (SI = 10.3), respectively.

Original language	English
Pages (from-to)	2224-2233
Number of pages	10
Journal	Journal of Natural Products
Volume	77
Issue number	10
DOIs	https://doi.org/10.1021/np5004752
Publication status	Published - 24 Oct 2014
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/np5004752

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title = "Eurifoloids A-R, structurally diverse diterpenoids from Euphorbia neriifolia",

abstract = "Eighteen new diterpenoids, named eurifoloids A-R (1-18), including ingenane (1 and 2), abietane (3-7), isopimarane (8-12), and ent-atisane (13-18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC50 values of 3.58 ± 0.31 (SI = 8.6) and 7.40 ± 0.94 M (SI = 10.3), respectively.",

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doi = "10.1021/np5004752",

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T1 - Eurifoloids A-R, structurally diverse diterpenoids from Euphorbia neriifolia

AU - Zhao, Jin Xin

AU - Liu, Cui Ping

AU - Qi, Wei Yan

AU - Han, Mei Ling

AU - Han, Ying Shan

AU - Wainberg, Mark A.

AU - Yue, Jian Min

PY - 2014/10/24

Y1 - 2014/10/24

N2 - Eighteen new diterpenoids, named eurifoloids A-R (1-18), including ingenane (1 and 2), abietane (3-7), isopimarane (8-12), and ent-atisane (13-18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC50 values of 3.58 ± 0.31 (SI = 8.6) and 7.40 ± 0.94 M (SI = 10.3), respectively.

AB - Eighteen new diterpenoids, named eurifoloids A-R (1-18), including ingenane (1 and 2), abietane (3-7), isopimarane (8-12), and ent-atisane (13-18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC50 values of 3.58 ± 0.31 (SI = 8.6) and 7.40 ± 0.94 M (SI = 10.3), respectively.

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SN - 0163-3864

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JO - Journal of Natural Products

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IS - 10

ER -

Eurifoloids A-R, structurally diverse diterpenoids from Euphorbia neriifolia

Abstract

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