Abstract
Ethyl lactate is an amphiphilic bio-based solvent with beneficial safety characteristics and ecotoxicity profile. The miscibility of ethyl lactate with water allows adjustments of the medium properties using aqueous solutions of various concentrations to achieve the desired reaction outcome. This review discuses current applications of ethyl lactate and its aqueous solutions as media for organic synthesis. The effectiveness of these media has been demonstrated in several coupling reactions, olefin metathesis, carbonyl group reactions, heterocyclizations, various multicomponent reactions and other chemical transformations. These reactions often benefit from the application of non-conventional energy sources (microwave, ultrasound, and visible light irradiation). The reaction yields are typically comparable or higher than that obtained in conventional solvents.
| Original language | English |
|---|---|
| Article number | 100322 |
| Number of pages | 14 |
| Journal | Sustainable Chemistry and Pharmacy |
| Volume | 18 |
| DOIs | |
| Publication status | Published - Dec 2020 |
Keywords
- Bio-based solvent
- Ethyl lactate
- Green solvent
- Multicomponent reactions
- Organic synthesis