Ethical issues associated with prenatal screening using non-invasive prenatal testing for sex chromosome aneuploidy

Molly Johnston; Chanelle Warton; Mark D. Pertile; Michelle Taylor-Sands; Martin B. Delatycki; Lisa Hui; Julian Savulescu; Catherine Mills

doi:10.1002/pd.6217

Ethical issues associated with prenatal screening using non-invasive prenatal testing for sex chromosome aneuploidy

Molly Johnston, Chanelle Warton, Mark D. Pertile, Michelle Taylor-Sands, Martin B. Delatycki, Lisa Hui, Julian Savulescu, Catherine Mills

Monash Bioethics Centre

Research output: Contribution to journal › Review Article › Research › peer-review

20 Citations (Scopus)

Abstract

Prenatal screening for sex chromosome aneuploidies (SCAs) is increasingly available through expanded non-invasive prenatal testing (NIPT). NIPT for SCAs raises complex ethical issues for clinical providers, prospective parents and future children. This paper discusses the ethical issues that arise around NIPT for SCAs and current guidelines and protocols for management. The first section outlines current practice and the limitations of NIPT for SCAs. It then outlines key guidelines before discussing the ethical issues raised by this use of NIPT. We conclude that while screening for SCAs should be made available for people seeking to use NIPT, its implementation requires careful consideration of what, when and how information is provided to users.

Original language	English
Pages (from-to)	226-234
Number of pages	9
Journal	Prenatal Diagnosis
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/pd.6217
Publication status	Published - Feb 2023

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10.1002/pd.6217Licence: CC BY-NC

399876532-oaFinal published version, 312 KBLicence: CC BY-NC

Cite this

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title = "Ethical issues associated with prenatal screening using non-invasive prenatal testing for sex chromosome aneuploidy",

abstract = "Prenatal screening for sex chromosome aneuploidies (SCAs) is increasingly available through expanded non-invasive prenatal testing (NIPT). NIPT for SCAs raises complex ethical issues for clinical providers, prospective parents and future children. This paper discusses the ethical issues that arise around NIPT for SCAs and current guidelines and protocols for management. The first section outlines current practice and the limitations of NIPT for SCAs. It then outlines key guidelines before discussing the ethical issues raised by this use of NIPT. We conclude that while screening for SCAs should be made available for people seeking to use NIPT, its implementation requires careful consideration of what, when and how information is provided to users.",

author = "Molly Johnston and Chanelle Warton and Pertile, {Mark D.} and Michelle Taylor-Sands and Delatycki, {Martin B.} and Lisa Hui and Julian Savulescu and Catherine Mills",

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AU - Delatycki, Martin B.

AU - Hui, Lisa

AU - Savulescu, Julian

AU - Mills, Catherine

N1 - Funding Information: Funding for this research is provided by the Australian Research Council Linkage Project Scheme, LP190100841. Illumina Inc. and Victorian Clinical Genetics Services provide partnership funding and in‐kind support for this research project under the Linkage Project Scheme. Publisher Copyright: © 2022 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.

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AB - Prenatal screening for sex chromosome aneuploidies (SCAs) is increasingly available through expanded non-invasive prenatal testing (NIPT). NIPT for SCAs raises complex ethical issues for clinical providers, prospective parents and future children. This paper discusses the ethical issues that arise around NIPT for SCAs and current guidelines and protocols for management. The first section outlines current practice and the limitations of NIPT for SCAs. It then outlines key guidelines before discussing the ethical issues raised by this use of NIPT. We conclude that while screening for SCAs should be made available for people seeking to use NIPT, its implementation requires careful consideration of what, when and how information is provided to users.

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Ethical issues associated with prenatal screening using non-invasive prenatal testing for sex chromosome aneuploidy

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Ethical, Social and Regulatory Issues in Advanced Prenatal Testing

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Ethical issues associated with prenatal screening using non-invasive prenatal testing for sex chromosome aneuploidy

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Ethical, Social and Regulatory Issues in Advanced Prenatal Testing

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