Ethanol and isolated traumatic brain injury

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21 Citations (Scopus)

Abstract

The aim of this systematic review was to determine whether ethanol is neuroprotective or associated with adverse effects in the context of traumatic brain injury (TBI). Approximately 30-60 of TBI patients are intoxicated with ethanol at the time of injury. We performed a systematic review of the literature using a combination of keywords for ethanol and TBI. Manuscripts were included if the population studied was human subjects with isolated moderate to severe TBI, acute ethanol intoxication was studied as an exposure variable and mortality reported as an outcome. The included studies were assessed for heterogeneity. A meta-analysis was performed and the pooled odds ratio (OR) for the association between ethanol and in-hospital mortality reported. There were seven studies eligible for analysis. A statistically significant association favouring reduced mortality with ethanol intoxication was found (OR 0.78; 95 confidence interval 0.73-0.83). Heterogeneity among selected studies was not statistically significant (p = 0.25). Following isolated moderate-severe TBI, ethanol intoxication was associated with reduced in-hospital mortality. The retrospective nature of the studies, varying definitions of brain injury, degree of intoxication and presence of potential confounders limits our confidence in this conclusion. Further research is recommended to explore the potential use of ethanol as a therapeutic strategy following TBI.
Original languageEnglish
Pages (from-to)1375 - 1381
Number of pages7
JournalJournal of Clinical Neuroscience
Volume22
Issue number9
DOIs
Publication statusPublished - 2015

Cite this

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title = "Ethanol and isolated traumatic brain injury",
abstract = "The aim of this systematic review was to determine whether ethanol is neuroprotective or associated with adverse effects in the context of traumatic brain injury (TBI). Approximately 30-60 of TBI patients are intoxicated with ethanol at the time of injury. We performed a systematic review of the literature using a combination of keywords for ethanol and TBI. Manuscripts were included if the population studied was human subjects with isolated moderate to severe TBI, acute ethanol intoxication was studied as an exposure variable and mortality reported as an outcome. The included studies were assessed for heterogeneity. A meta-analysis was performed and the pooled odds ratio (OR) for the association between ethanol and in-hospital mortality reported. There were seven studies eligible for analysis. A statistically significant association favouring reduced mortality with ethanol intoxication was found (OR 0.78; 95 confidence interval 0.73-0.83). Heterogeneity among selected studies was not statistically significant (p = 0.25). Following isolated moderate-severe TBI, ethanol intoxication was associated with reduced in-hospital mortality. The retrospective nature of the studies, varying definitions of brain injury, degree of intoxication and presence of potential confounders limits our confidence in this conclusion. Further research is recommended to explore the potential use of ethanol as a therapeutic strategy following TBI.",
author = "Brennan, {James Harold} and Bernard, {Stephen Anthony} and Peter Cameron and Rosenfeld, {Jeffrey Victor} and Biswadev Mitra",
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Ethanol and isolated traumatic brain injury. / Brennan, James Harold; Bernard, Stephen Anthony; Cameron, Peter; Rosenfeld, Jeffrey Victor; Mitra, Biswadev.

In: Journal of Clinical Neuroscience, Vol. 22, No. 9, 2015, p. 1375 - 1381.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Cameron, Peter

AU - Rosenfeld, Jeffrey Victor

AU - Mitra, Biswadev

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