Ethambutol was discovered at Lederle Laboratories in 1961, when randomly selected synthetic compounds were being tested for antituberculosis activity. Chemically, it is dextro-2, 2'-(ethylenediimino)-di-1-butanol dihydrochloride, and it has a high degree of activity against Mycobacterium tuberculosis (Thomas et al., 1961). The chemical formula of ethambutol dihydrochloride is C10H24N2O2. 2(HCl) and its molecular weight is 277.23; its molecular structure is shown in Figure 124.1. Ethambutol is a useful drug for the treatment of tuberculosis and infections due to Mycobacterium avium complex and other nontuberculous mycobacteria.
|Title of host publication||Kucers the Use of Antibiotics|
|Subtitle of host publication||A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs|
|Editors||M. Lindsay Grayson|
|Place of Publication||Boca Raton FL USA|
|Number of pages||15|
|Publication status||Published - 2 Oct 2017|