Ethambutol

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Abstract

Ethambutol was discovered at Lederle Laboratories in 1961, when randomly selected synthetic compounds were being tested for antituberculosis activity. Chemically, it is dextro-2, 2'-(ethylenediimino)-di-1-butanol dihydrochloride, and it has a high degree of activity against Mycobacterium tuberculosis (Thomas et al., 1961). The chemical formula of ethambutol dihydrochloride is C10H24N2O2. 2(HCl) and its molecular weight is 277.23; its molecular structure is shown in Figure 124.1. Ethambutol is a useful drug for the treatment of tuberculosis and infections due to Mycobacterium avium complex and other nontuberculous mycobacteria.

Original languageEnglish
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs
EditorsM. Lindsay Grayson
Place of PublicationBoca Raton FL USA
PublisherCRC Press
Chapter124
Pages2346-2360
Number of pages15
Edition7th
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
Publication statusPublished - 2 Oct 2017

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