Estrogens and men with schizophrenia: Is there a case for adjunctive therapy?

Jayashri Kulkarni, Rolet Anthony De Castella, Barbara Headey, Natasha Marston, Kelly Sinclair, Stuart Lee, Caroline Gurvich, Paul Fitzgerald, Henry Burger

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)


The current 14-day randomised placebo-controlled trial in 53 men with schizophrenia was conducted to evaluate the efficacy of 2 mg oral estradiol valerate as an adjunct to atypical antipsychotic treatment. Results demonstrated for estradiol participants a more rapid reduction in general psychopathology that occurred in the context of greater increases in serum estrogen levels and reductions in FSH and testosterone levels
Original languageEnglish
Pages (from-to)278 - 283
Number of pages5
JournalSchizophrenia Research
Publication statusPublished - 2011

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