Estradiol prevents fat accumulation and overcomes leptin resistance in female high-fat diet mice

Sara Alejandra Litwak, Jenny Lisa Wendy Wilson, Weiyi Chen, Maria Cecilia Garcia-Rudaz, Mohammad Khaksari, Michael A Cowley, Pablo Enriori

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51 Citations (Scopus)


In pre-menopausal and menopausal women in particular, suboptimal estrogens have been linked to the development of the metabolic syndrome as major contributors to fat accumulation. At the same time, estrogens have been described to have a role in regulating body metabolic status. We evaluated how endogenous or administered estrogens impact on the changes associated with high fat diet (HFD) consumption in two different paradigms; ovarian-intact and in ovariectomized (OVX) mice. When estradiol (E2) was cyclically administered to ovarian-intact HFD fed mice for twelve weeks, animals gained significantly less weight than ovarian-intact vehicle controls (p
Original languageEnglish
Pages (from-to)4447 - 4460
Number of pages14
Issue number11
Publication statusPublished - 2014

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