Projects per year
Abstract
In pre-menopausal and menopausal women in particular, suboptimal estrogens have been linked to the development of the metabolic syndrome as major contributors to fat accumulation. At the same time, estrogens have been described to have a role in regulating body metabolic status. We evaluated how endogenous or administered estrogens impact on the changes associated with high fat diet (HFD) consumption in two different paradigms; ovarian-intact and in ovariectomized (OVX) mice. When estradiol (E2) was cyclically administered to ovarian-intact HFD fed mice for twelve weeks, animals gained significantly less weight than ovarian-intact vehicle controls (p
Original language | English |
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Pages (from-to) | 4447 - 4460 |
Number of pages | 14 |
Journal | Endocrinology |
Volume | 155 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2014 |
Projects
- 1 Finished
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Does loss of melanocortin glucose sensing contribute to obesity induced diabetes?
Cowley, M., Enriori, P. & Tiganis, T.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/10 → 31/12/12
Project: Research