Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut

David P. Wilson, Joseph J. Mattapallil, Matthew D.H. Lay, Lei Zhang, Mario Roederer, Miles P. Davenport

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)


CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIVmac251 viral load in blood and CD4 + T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIVmac251 is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIYmac251. Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.

Original languageEnglish
Pages (from-to)8025-8029
Number of pages5
JournalJournal of Virology
Issue number15
Publication statusPublished - Aug 2007

Cite this