Estimating fetal gestational age using cardiac valve intervals

Faezeh Marzbanrad, Ahsan Khandoker, Yoshitaka Kimura, Marimuthu Palaniswami, Gari D Clifford

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

5 Citations (Scopus)


A new automated method for estimation of the gestational age is presented in this paper based on the intervals between fetal cardiac valve timings and the Q-wave of fetal electrocardiogram (fECG). The intervals were estimated automatically from one-dimensional Doppler Ultrasound and noninvasive fECG. Among the intervals, Isovolumic Contraction Time, Electromechanical Delay Time, Ventricular Filling Time and their interactions were selected in a stepwise regression process. Compared with Crown-Rump Length as gold standard, a mean absolute error of 3.8 weeks was obtained using leave-one-out cross validation. This method also outperformed a fetal heart rate based approach. Since valve intervals reflect the autonomic function, this method provides a novel measure of the development of fetal autonomic nervous system that may be growth curve independent.
Original languageEnglish
Title of host publicationComputing in Cardiology 2016
Subtitle of host publicationSeptember 11-14, 2016, Vancouver, Canada [proceedings]
EditorsAlan Murray
Place of PublicationVancouver, Canada
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages4
ISBN (Electronic)9781509008957
ISBN (Print)9781509008964
Publication statusPublished - 2016
EventComputing in Cardiology Conference 2016 - Vancouver, Canada
Duration: 11 Sep 201614 Sep 2016
Conference number: 43rd


ConferenceComputing in Cardiology Conference 2016
Abbreviated titleCINC 2016
Internet address

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