Estimates of chronic hepatitis B virus infection in Australia, 2000

Belinda G. O'Sullivan, Heather F. Gidding, Matthew Law, John M. Kaldor, Gwendolyn L. Gilbert, Gregory J. Dore

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Abstract

Objectives: To estimate the prevalence of chronic hepatitis B virus (HBV) infection in Australia and attributable proportions associated with specific demographic groups at higher risk of infection. Methods: Two methods were used to estimate prevalence of HBV surface antigen (HBsAg): (1) Population-based: results of a national serosurvey using sera collected opportunistically from laboratories across Australia were used for 1-59 year olds, with the HBsAg prevalence for 50-59 years extrapolated to the population aged 60 years and over; (2) Risk group-based: estimates for selected high-risk groups (injecting drug users, homosexual men, Indigenous Australians and people born in high-prevalence countries), using source data from antenatal HBV screening in central Sydney, HBV prevalence studies, and estimates for low-risk groups (first-time blood donors) were combined proportionally to their representation in the population. Results: Prevalence of HBsAg in the national serosurvey increased, with age, from 0.0% for 1-4 and 5-9 year olds to 1.3-1.8% for the 40-49 year age group. Australian population HBsAg prevalence based on minimum and adjusted estimates from this serosurvey were 91,500 (0.49%) and 163,000 (0.87%) infections, respectively. The risk group method estimated an Australian HBsAg prevalence of 88,000 infections (0.47%). Approximately 50% of people with chronic HBV infection were estimated to be immigrants from either South-East Asia (33.3%) or North-East Asia (16.2%). Conclusion: The range of estimates for chronic HBV infection in Australia is broad, reflecting the uncertainty in source data. A national blood survey encompassing a large and representative population sample may help to provide more accurate estimates. A large proportion of people with chronic HBV infection are Asian born.

Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalAustralian and New Zealand Journal of Public Health
Volume28
Issue number3
Publication statusPublished - 2004
Externally publishedYes

Cite this

O'Sullivan, B. G., Gidding, H. F., Law, M., Kaldor, J. M., Gilbert, G. L., & Dore, G. J. (2004). Estimates of chronic hepatitis B virus infection in Australia, 2000. Australian and New Zealand Journal of Public Health, 28(3), 212-216.
O'Sullivan, Belinda G. ; Gidding, Heather F. ; Law, Matthew ; Kaldor, John M. ; Gilbert, Gwendolyn L. ; Dore, Gregory J. / Estimates of chronic hepatitis B virus infection in Australia, 2000. In: Australian and New Zealand Journal of Public Health. 2004 ; Vol. 28, No. 3. pp. 212-216.
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abstract = "Objectives: To estimate the prevalence of chronic hepatitis B virus (HBV) infection in Australia and attributable proportions associated with specific demographic groups at higher risk of infection. Methods: Two methods were used to estimate prevalence of HBV surface antigen (HBsAg): (1) Population-based: results of a national serosurvey using sera collected opportunistically from laboratories across Australia were used for 1-59 year olds, with the HBsAg prevalence for 50-59 years extrapolated to the population aged 60 years and over; (2) Risk group-based: estimates for selected high-risk groups (injecting drug users, homosexual men, Indigenous Australians and people born in high-prevalence countries), using source data from antenatal HBV screening in central Sydney, HBV prevalence studies, and estimates for low-risk groups (first-time blood donors) were combined proportionally to their representation in the population. Results: Prevalence of HBsAg in the national serosurvey increased, with age, from 0.0{\%} for 1-4 and 5-9 year olds to 1.3-1.8{\%} for the 40-49 year age group. Australian population HBsAg prevalence based on minimum and adjusted estimates from this serosurvey were 91,500 (0.49{\%}) and 163,000 (0.87{\%}) infections, respectively. The risk group method estimated an Australian HBsAg prevalence of 88,000 infections (0.47{\%}). Approximately 50{\%} of people with chronic HBV infection were estimated to be immigrants from either South-East Asia (33.3{\%}) or North-East Asia (16.2{\%}). Conclusion: The range of estimates for chronic HBV infection in Australia is broad, reflecting the uncertainty in source data. A national blood survey encompassing a large and representative population sample may help to provide more accurate estimates. A large proportion of people with chronic HBV infection are Asian born.",
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O'Sullivan, BG, Gidding, HF, Law, M, Kaldor, JM, Gilbert, GL & Dore, GJ 2004, 'Estimates of chronic hepatitis B virus infection in Australia, 2000', Australian and New Zealand Journal of Public Health, vol. 28, no. 3, pp. 212-216.

Estimates of chronic hepatitis B virus infection in Australia, 2000. / O'Sullivan, Belinda G.; Gidding, Heather F.; Law, Matthew; Kaldor, John M.; Gilbert, Gwendolyn L.; Dore, Gregory J.

In: Australian and New Zealand Journal of Public Health, Vol. 28, No. 3, 2004, p. 212-216.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Dore, Gregory J.

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N2 - Objectives: To estimate the prevalence of chronic hepatitis B virus (HBV) infection in Australia and attributable proportions associated with specific demographic groups at higher risk of infection. Methods: Two methods were used to estimate prevalence of HBV surface antigen (HBsAg): (1) Population-based: results of a national serosurvey using sera collected opportunistically from laboratories across Australia were used for 1-59 year olds, with the HBsAg prevalence for 50-59 years extrapolated to the population aged 60 years and over; (2) Risk group-based: estimates for selected high-risk groups (injecting drug users, homosexual men, Indigenous Australians and people born in high-prevalence countries), using source data from antenatal HBV screening in central Sydney, HBV prevalence studies, and estimates for low-risk groups (first-time blood donors) were combined proportionally to their representation in the population. Results: Prevalence of HBsAg in the national serosurvey increased, with age, from 0.0% for 1-4 and 5-9 year olds to 1.3-1.8% for the 40-49 year age group. Australian population HBsAg prevalence based on minimum and adjusted estimates from this serosurvey were 91,500 (0.49%) and 163,000 (0.87%) infections, respectively. The risk group method estimated an Australian HBsAg prevalence of 88,000 infections (0.47%). Approximately 50% of people with chronic HBV infection were estimated to be immigrants from either South-East Asia (33.3%) or North-East Asia (16.2%). Conclusion: The range of estimates for chronic HBV infection in Australia is broad, reflecting the uncertainty in source data. A national blood survey encompassing a large and representative population sample may help to provide more accurate estimates. A large proportion of people with chronic HBV infection are Asian born.

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