Abstract
Original language | English |
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Article number | e0117241 |
Number of pages | 13 |
Journal | PLoS ONE |
Volume | 10 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2015 |
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Establishing the natural history and growth rate of ameloblastoma with implications for management: Systematic review and meta-analysis. / Chae, Michael Park; Smoll, Nicolas; Hunter-Smith, David James; Rozen, Warren M.
In: PLoS ONE, Vol. 10, No. 2, e0117241, 2015.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Establishing the natural history and growth rate of ameloblastoma with implications for management: Systematic review and meta-analysis
AU - Chae, Michael Park
AU - Smoll, Nicolas
AU - Hunter-Smith, David James
AU - Rozen, Warren M
PY - 2015
Y1 - 2015
N2 - Background: Ameloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature. Method: A systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article s level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma. Results: Literature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84 per year. Conclusion: The growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged. ? 2015 Chae et al.
AB - Background: Ameloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature. Method: A systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article s level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma. Results: Literature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84 per year. Conclusion: The growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged. ? 2015 Chae et al.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338260/pdf/pone.0117241.pdf
U2 - 10.1371/journal.pone.0117241
DO - 10.1371/journal.pone.0117241
M3 - Article
VL - 10
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 2
M1 - e0117241
ER -