Establishing the natural history and growth rate of ameloblastoma with implications for management: Systematic review and meta-analysis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Ameloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature. Method: A systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article s level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma. Results: Literature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84 per year. Conclusion: The growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged. ? 2015 Chae et al.
Original languageEnglish
Article numbere0117241
Number of pages13
JournalPLoS ONE
Volume10
Issue number2
DOIs
Publication statusPublished - 2015

Cite this

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title = "Establishing the natural history and growth rate of ameloblastoma with implications for management: Systematic review and meta-analysis",
abstract = "Background: Ameloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature. Method: A systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article s level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma. Results: Literature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84 per year. Conclusion: The growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged. ? 2015 Chae et al.",
author = "Chae, {Michael Park} and Nicolas Smoll and Hunter-Smith, {David James} and Rozen, {Warren M}",
year = "2015",
doi = "10.1371/journal.pone.0117241",
language = "English",
volume = "10",
journal = "PLoS ONE",
issn = "1932-6203",
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Establishing the natural history and growth rate of ameloblastoma with implications for management: Systematic review and meta-analysis. / Chae, Michael Park; Smoll, Nicolas; Hunter-Smith, David James; Rozen, Warren M.

In: PLoS ONE, Vol. 10, No. 2, e0117241, 2015.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Establishing the natural history and growth rate of ameloblastoma with implications for management: Systematic review and meta-analysis

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PY - 2015

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N2 - Background: Ameloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature. Method: A systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article s level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma. Results: Literature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84 per year. Conclusion: The growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged. ? 2015 Chae et al.

AB - Background: Ameloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature. Method: A systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article s level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma. Results: Literature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84 per year. Conclusion: The growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged. ? 2015 Chae et al.

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