Establishing the Melbourne Injecting Drug User Cohort Study (MIX): rationale, methods, and baseline and twelve-month follow-up results

Danielle Horyniak, Peter Higgs, Rebecca Anne Jenkinson, Louise Degenhardt, Mark Stoove, Thomas Kerr, Matthew Hickman, Campbell Kynoch Aitken, Paul Mark Dietze

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Cohort studies provide an excellent opportunity to monitor changes in behaviour and disease transmission over time. In Australia, cohort studies of people who inject drugs (PWID) have generally focused on older, in-treatment injectors, with only limited outcome measure data collected. In this study we specifically sought to recruit a sample of younger, largely out-of-treatment PWID, in order to study the trajectories of their drug use over time. METHODS: Respondent driven sampling, traditional snowball sampling and street outreach methods were used to recruit heroin and amphetamine injectors from one outer-urban and two inner-urban regions of Melbourne, Australia. Information was collected on participants demographic and social characteristics, drug use characteristics, drug market access patterns, health and social functioning, and health service utilisation. Participants are followed-up on an annual basis. RESULTS: 688 PWID were recruited into the study. At baseline, the median age of participants was 27.6 years (IQR: 24.4 years - 29.6 years) and two-thirds (67 ) were male. Participants reported injecting for a median of 10.2 years (range: 1.5 months - 21.2 years), with 11 having injected for three years or less. Limited education, unemployment and previous incarceration were common. The majority of participants (82 ) reported recent heroin injection, and one third reported being enrolled in Opioid Substitution Therapy (OST) at recruitment. At 12 months follow-up 458 participants (71 of eligible participants) were retained in the study. There were few differences in demographic and drug-use characteristics of those lost to follow-up compared with those retained in the study, with attrition significantly associated with recruitment at an inner-urban location, male gender, and providing incomplete contact information at baseline. CONCLUSIONS: Our efforts to recruit a sample of largely out-of-treatment PWID were limited by drug market
Original languageEnglish
Article number11
Pages (from-to)1 - 14
Number of pages14
JournalHarm Reduction Journal
Issue number1
Publication statusPublished - 2013

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