Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model

Arjan B Te Pas, Melissa Li-Lian Siew, Megan Jane Wallace, Marcus John Kitchen, Andreas Fouras, Robert A Lewis, Naoto Yagi, Kentaro Uesugi, Susan Donath, Peter G Davis, Colin J Morley, Stuart Brian Hooper

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Abstract

The effect of inflation length on lung aeration pattern, tidal volumes and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 days), randomized into 4 groups, received a 1, 5, 10, or 20 sec inflation (SI) followed by ventilation with 5 cmH2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast X-ray imaging for 7 minutes. The first inspiratory volume significantly (p
Original languageEnglish
Pages (from-to)537 - 541
Number of pages5
JournalPediatric Research
Volume65
Issue number5
DOIs
Publication statusPublished - 2009

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