Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model

Arjan B Te Pas; Melissa Li-Lian Siew; Megan Jane Wallace; Marcus John Kitchen; Andreas Fouras; Robert A Lewis; Naoto Yagi; Kentaro Uesugi; Susan Donath; Peter G Davis; Colin J Morley; Stuart Brian Hooper

doi:10.1203/PDR.0b013e31819da21b

Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model

Arjan B Te Pas, Melissa Li-Lian Siew, Megan Jane Wallace, Marcus John Kitchen, Andreas Fouras, Robert A Lewis, Naoto Yagi, Kentaro Uesugi, Susan Donath, Peter G Davis, Colin J Morley, Stuart Brian Hooper

Physiology

Research output: Contribution to journal › Article › Research › peer-review

164 Citations (Scopus)

Abstract

The effect of inflation length on lung aeration pattern, tidal volumes and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 days), randomized into 4 groups, received a 1, 5, 10, or 20 sec inflation (SI) followed by ventilation with 5 cmH2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast X-ray imaging for 7 minutes. The first inspiratory volume significantly (p

Original language	English
Pages (from-to)	537 - 541
Number of pages	5
Journal	Pediatric Research
Volume	65
Issue number	5
DOIs	https://doi.org/10.1203/PDR.0b013e31819da21b
Publication status	Published - 2009

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Te Pas, A. B., Siew, M. L.-L., Wallace, M. J., Kitchen, M. J., Fouras, A., Lewis, R. A., Yagi, N., Uesugi, K., Donath, S., Davis, P. G., Morley, C. J., & Hooper, S. B. (2009). Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model. Pediatric Research, 65(5), 537 - 541. https://doi.org/10.1203/PDR.0b013e31819da21b

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title = "Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model",

abstract = "The effect of inflation length on lung aeration pattern, tidal volumes and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 days), randomized into 4 groups, received a 1, 5, 10, or 20 sec inflation (SI) followed by ventilation with 5 cmH2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast X-ray imaging for 7 minutes. The first inspiratory volume significantly (p",

author = "{Te Pas}, {Arjan B} and Siew, {Melissa Li-Lian} and Wallace, {Megan Jane} and Kitchen, {Marcus John} and Andreas Fouras and Lewis, {Robert A} and Naoto Yagi and Kentaro Uesugi and Susan Donath and Davis, {Peter G} and Morley, {Colin J} and Hooper, {Stuart Brian}",

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Te Pas, AB, Siew, ML-L, Wallace, MJ , Kitchen, MJ, Fouras, A, Lewis, RA, Yagi, N, Uesugi, K, Donath, S, Davis, PG, Morley, CJ & Hooper, SB 2009, 'Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model', Pediatric Research, vol. 65, no. 5, pp. 537 - 541. https://doi.org/10.1203/PDR.0b013e31819da21b

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T1 - Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model

AU - Te Pas, Arjan B

AU - Siew, Melissa Li-Lian

AU - Wallace, Megan Jane

AU - Kitchen, Marcus John

AU - Fouras, Andreas

AU - Lewis, Robert A

AU - Yagi, Naoto

AU - Uesugi, Kentaro

AU - Donath, Susan

AU - Davis, Peter G

AU - Morley, Colin J

AU - Hooper, Stuart Brian

PY - 2009

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AB - The effect of inflation length on lung aeration pattern, tidal volumes and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 days), randomized into 4 groups, received a 1, 5, 10, or 20 sec inflation (SI) followed by ventilation with 5 cmH2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast X-ray imaging for 7 minutes. The first inspiratory volume significantly (p

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DO - 10.1203/PDR.0b013e31819da21b

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VL - 65

SP - 537

EP - 541

JO - Pediatric Research

JF - Pediatric Research

IS - 5

ER -

Establishing functional residual capacity at birth: The effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model

Abstract

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