Essential fatty acid deficiency increases interstitial IA-positive cells in rat kidney and accelerates renal allograft rejection

Anthony J.F. D'apice, Sharon Kalina, Adrienne McKenzie, Mary Polihronis, Patricia Eadie, Bronwyn Pollock, Martin J. Pearse, Andrew J. Sinclair, Bernard M. O'brien

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2 Citations (Scopus)


Essential fatty acid deficiency has been reported to result in depletion of interstitial macrophages from rat kidneys and to permit transplantation of these kidneys across a fully allogeneic barrier without need for immunosuppression. In view of the potential for application of this phenomenon to xenografts, this study attempted to confirm the observation. Kidneys from rats fed normal or essential fatty-acid-deficient diets were transplanted to DA recipients. The donors' livers and contralateral kidneys were analyzed for their fatty acid profile in liver phospholipids, and the kidneys were examined by immunohistology for interstitial Ia(+) cells. EFAD resulted in an increase in renal interstitial Ia(+) cells detected by MRC-OX6 (anti-RTlBpubHc) from 13.5 ± 2.9 (control diet fed rats) to 22.8 ± 3.6 in rats on a stringent EFAD diet. Graft survival of kidneys from these EFAD rats was significantly shorter than that of kidneys from control diet fed rats. In direct contrast to the original report, this study found that EFAD caused a marked increase in renal interstitial Ia(+) cells and a reduction in allograft survival of EFAD donor kidneys.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
Issue number2
Publication statusPublished - 1 Jan 1993
Externally publishedYes

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