Esophageal stem cells - A review of their identification and characterization

Daniel Croagh, Robert J.S. Thomas, Wayne A. Phillips, Pritinder Kaur

Research output: Contribution to journalReview ArticleResearchpeer-review

32 Citations (Scopus)

Abstract

The incidence of adenocarcinoma of the esophagus has increased faster than any other internal malignancy over the last 40 years. Despite this, surprisingly little is known about the basic biology of this tissue, particularly with regards to the organization of cell proliferation within the epithelium. This is a matter of crucial importance for our understanding of the pathogenesis of esophageal cancer. Nevertheless, significant advances have recently been made in the identification and functional characterization of both murine and human esophageal stem cells and their progeny in recent years. This places investigators in an exciting position to gain further insights into the processes of tissue renewal and repair on the one hand and the development of dysplasia and malignancy on the other.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalStem Cell Reviews
Volume4
Issue number4
DOIs
Publication statusPublished - 1 Dec 2008
Externally publishedYes

Keywords

  • Cancer
  • Differentiation
  • Esophagus
  • Stem cells

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