Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

Sita R. Dewamitta; Chacko Joseph; Louise E. Purton; Carl R. Walkley

doi:10.1111/bjh.12578

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

Sita R. Dewamitta, Chacko Joseph, Louise E. Purton, Carl R. Walkley

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARγ^-/- mice were anaemic, however, Epor-Cre Rara^fl/fl, Epor-Cre Rarg^fl/fl and Epor-Cre Rara^fl/flg^fl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RARγ plays an erythroid extrinsic role in erythropoiesis.

Original language	English
Pages (from-to)	280-285
Number of pages	6
Journal	British Journal of Haematology
Volume	164
Issue number	2
DOIs	https://doi.org/10.1111/bjh.12578
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

Anaemia
Erythroid development
Experimental haematology
Retinoic acid
Vitamin A

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10.1111/bjh.12578

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title = "Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors",

abstract = "Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARγ-/- mice were anaemic, however, Epor-Cre Rarafl/fl, Epor-Cre Rargfl/fl and Epor-Cre Rarafl/flgfl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RARγ plays an erythroid extrinsic role in erythropoiesis.",

keywords = "Anaemia, Erythroid development, Experimental haematology, Retinoic acid, Vitamin A",

author = "Dewamitta, \{Sita R.\} and Chacko Joseph and Purton, \{Louise E.\} and Walkley, \{Carl R.\}",

year = "2014",

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doi = "10.1111/bjh.12578",

language = "English",

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journal = "British Journal of Haematology",

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T1 - Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

AU - Dewamitta, Sita R.

AU - Joseph, Chacko

AU - Purton, Louise E.

AU - Walkley, Carl R.

PY - 2014/1

Y1 - 2014/1

N2 - Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARγ-/- mice were anaemic, however, Epor-Cre Rarafl/fl, Epor-Cre Rargfl/fl and Epor-Cre Rarafl/flgfl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RARγ plays an erythroid extrinsic role in erythropoiesis.

AB - Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARγ-/- mice were anaemic, however, Epor-Cre Rarafl/fl, Epor-Cre Rargfl/fl and Epor-Cre Rarafl/flgfl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RARγ plays an erythroid extrinsic role in erythropoiesis.

KW - Anaemia

KW - Erythroid development

KW - Experimental haematology

KW - Retinoic acid

KW - Vitamin A

UR - https://www.scopus.com/pages/publications/84891631069

U2 - 10.1111/bjh.12578

DO - 10.1111/bjh.12578

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AN - SCOPUS:84891631069

SN - 0007-1048

VL - 164

SP - 280

EP - 285

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

Abstract

Keywords

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