Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

Sita R. Dewamitta, Chacko Joseph, Louise E. Purton, Carl R. Walkley

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16 Citations (Scopus)

Abstract

Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARγ-/- mice were anaemic, however, Epor-Cre Rarafl/fl, Epor-Cre Rargfl/fl and Epor-Cre Rarafl/flgfl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RARγ plays an erythroid extrinsic role in erythropoiesis.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalBritish Journal of Haematology
Volume164
Issue number2
DOIs
Publication statusPublished - Jan 2014
Externally publishedYes

Keywords

  • Anaemia
  • Erythroid development
  • Experimental haematology
  • Retinoic acid
  • Vitamin A

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