Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps

Luke J. Norman, Stephan F Taylor, Yanni Liu, Joaquim Radua, Yann Chye, Stella J. De Witt, Chaim Huyser, F. Isik Karahanoglu, Tracy Luks, Dara Manoach, Carol Mathews, Katya Rubia, Chao Suo, Odile A. van den Heuvel, Murat Yucel, Kate Fitzgerald

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p = .03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p = .02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p < .001). Conclusions A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.
Original languageEnglish
Pages (from-to)713-725
Number of pages13
JournalBiological Psychiatry
Volume85
Issue number9
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • error processing
  • fMRI
  • inhibitory control
  • meta-analysis
  • OCD
  • performance monitoring

Cite this

Norman, Luke J. ; Taylor, Stephan F ; Liu, Yanni ; Radua, Joaquim ; Chye, Yann ; De Witt, Stella J. ; Huyser, Chaim ; Karahanoglu, F. Isik ; Luks, Tracy ; Manoach, Dara ; Mathews, Carol ; Rubia, Katya ; Suo, Chao ; van den Heuvel, Odile A. ; Yucel, Murat ; Fitzgerald, Kate. / Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps. In: Biological Psychiatry. 2019 ; Vol. 85, No. 9. pp. 713-725.
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abstract = "Background Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p = .03, 95{\%} confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p = .02, 95{\%} confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p < .001). Conclusions A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.",
keywords = "error processing, fMRI, inhibitory control, meta-analysis, OCD, performance monitoring",
author = "Norman, {Luke J.} and Taylor, {Stephan F} and Yanni Liu and Joaquim Radua and Yann Chye and {De Witt}, {Stella J.} and Chaim Huyser and Karahanoglu, {F. Isik} and Tracy Luks and Dara Manoach and Carol Mathews and Katya Rubia and Chao Suo and {van den Heuvel}, {Odile A.} and Murat Yucel and Kate Fitzgerald",
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Norman, LJ, Taylor, SF, Liu, Y, Radua, J, Chye, Y, De Witt, SJ, Huyser, C, Karahanoglu, FI, Luks, T, Manoach, D, Mathews, C, Rubia, K, Suo, C, van den Heuvel, OA, Yucel, M & Fitzgerald, K 2019, 'Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps' Biological Psychiatry, vol. 85, no. 9, pp. 713-725. https://doi.org/10.1016/j.biopsych.2018.11.010

Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps. / Norman, Luke J.; Taylor, Stephan F; Liu, Yanni; Radua, Joaquim; Chye, Yann; De Witt, Stella J.; Huyser, Chaim; Karahanoglu, F. Isik; Luks, Tracy; Manoach, Dara; Mathews, Carol; Rubia, Katya; Suo, Chao; van den Heuvel, Odile A.; Yucel, Murat; Fitzgerald, Kate.

In: Biological Psychiatry, Vol. 85, No. 9, 01.05.2019, p. 713-725.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps

AU - Norman, Luke J.

AU - Taylor, Stephan F

AU - Liu, Yanni

AU - Radua, Joaquim

AU - Chye, Yann

AU - De Witt, Stella J.

AU - Huyser, Chaim

AU - Karahanoglu, F. Isik

AU - Luks, Tracy

AU - Manoach, Dara

AU - Mathews, Carol

AU - Rubia, Katya

AU - Suo, Chao

AU - van den Heuvel, Odile A.

AU - Yucel, Murat

AU - Fitzgerald, Kate

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p = .03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p = .02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p < .001). Conclusions A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.

AB - Background Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p = .03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p = .02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p < .001). Conclusions A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.

KW - error processing

KW - fMRI

KW - inhibitory control

KW - meta-analysis

KW - OCD

KW - performance monitoring

U2 - 10.1016/j.biopsych.2018.11.010

DO - 10.1016/j.biopsych.2018.11.010

M3 - Article

VL - 85

SP - 713

EP - 725

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 9

ER -