Epitope discovery and their use in peptide based vaccines

Nadine L Dudek, Patrick Perlmutter, Marie Isabel Aguilar, Nathan Croft, Anthony Wayne Purcell

Research output: Contribution to journalArticleResearchpeer-review

Abstract

With recent advances in the design and delivery of peptide-based therapeutics there has been a growing interest on the use of peptides in vaccine design. Moreover, functional dissection and proteomic analysis of the immunogenic epitopes of proteins from pathogenic micro-organisms, cancers and self-tissues targeted by autoimmune responses, have broadened the range of target epitopes and given clues to enhancing peptide immunogenicity. Consistent with these observations; peptides can be synthesised with defined chemical modifications to mimic natural epitopes and/or deliberately introduce protease resistant peptide bonds to regulate their processing independent of tissue specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer and review recent developments in the field of epitope discovery and peptide-based vaccines.
Original languageEnglish
Pages (from-to)3149 - 3157
Number of pages9
JournalCurrent Pharmaceutical Design
Volume16
Issue number28
Publication statusPublished - 2010

Cite this

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Epitope discovery and their use in peptide based vaccines. / Dudek, Nadine L; Perlmutter, Patrick; Aguilar, Marie Isabel; Croft, Nathan; Purcell, Anthony Wayne.

In: Current Pharmaceutical Design, Vol. 16, No. 28, 2010, p. 3149 - 3157.

Research output: Contribution to journalArticleResearchpeer-review

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