Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases

Mitchell G. Lawrence; Tara L. Veveris-Lowe; Astrid K. Whitbread; David L. Nicol; Judith A. Clements

doi:10.1159/000101311

Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases

Mitchell G. Lawrence
, Tara L. Veveris-Lowe
, Astrid K. Whitbread
, David L. Nicol
, Judith A. Clements

Research output: Contribution to journal › Article › Research › peer-review

30 Citations (Scopus)

Abstract

Prostate cancer is associated with significant mortality once the tumour has spread outside the gland. Epithelial-mesenchymal transition (EMT) has been proposed to facilitate this dissemination of tumour cells. In this article we summarize the evidence for EMT in prostate cancer, drawing on the expression of EMT-related markers and the functions of factors known to induce EMT in other systems. We also discuss our recent findings that two members of the tissue kallikrein family of serine proteases, prostate-specific antigen (PSA/KLK3) and kallikrein-related peptidase 4 (KLK4), lead to EMT-like changes in PC3 prostate cancer cells.

Original language	English
Pages (from-to)	111-115
Number of pages	5
Journal	Cells Tissues Organs
Volume	185
Issue number	1-3
DOIs	https://doi.org/10.1159/000101311
Publication status	Published - Jun 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

E-cadherin
Epithelial-mesenchymal transition
Kallikrein
Prostate
Prostate-specific antigen

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10.1159/000101311

Cite this

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abstract = "Prostate cancer is associated with significant mortality once the tumour has spread outside the gland. Epithelial-mesenchymal transition (EMT) has been proposed to facilitate this dissemination of tumour cells. In this article we summarize the evidence for EMT in prostate cancer, drawing on the expression of EMT-related markers and the functions of factors known to induce EMT in other systems. We also discuss our recent findings that two members of the tissue kallikrein family of serine proteases, prostate-specific antigen (PSA/KLK3) and kallikrein-related peptidase 4 (KLK4), lead to EMT-like changes in PC3 prostate cancer cells.",

keywords = "E-cadherin, Epithelial-mesenchymal transition, Kallikrein, Prostate, Prostate-specific antigen",

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year = "2007",

month = jun,

doi = "10.1159/000101311",

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AU - Veveris-Lowe, Tara L.

AU - Whitbread, Astrid K.

AU - Nicol, David L.

AU - Clements, Judith A.

PY - 2007/6

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AB - Prostate cancer is associated with significant mortality once the tumour has spread outside the gland. Epithelial-mesenchymal transition (EMT) has been proposed to facilitate this dissemination of tumour cells. In this article we summarize the evidence for EMT in prostate cancer, drawing on the expression of EMT-related markers and the functions of factors known to induce EMT in other systems. We also discuss our recent findings that two members of the tissue kallikrein family of serine proteases, prostate-specific antigen (PSA/KLK3) and kallikrein-related peptidase 4 (KLK4), lead to EMT-like changes in PC3 prostate cancer cells.

KW - E-cadherin

KW - Epithelial-mesenchymal transition

KW - Kallikrein

KW - Prostate

KW - Prostate-specific antigen

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JO - Cells Tissues Organs

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ER -

Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases

Abstract

UN SDGs

Keywords

Access to Document

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