Epiretinal electrical stimulation and the inner limiting membrane in rat retina

Shaun L. Cloherty; Raymond C. S. Wong; Alex E. Hadjinicolaou; Hamish Meffin; Michael R. Ibbotson; Brendan J. O'Brien

doi:10.1109/EMBC.2012.6346592

Epiretinal electrical stimulation and the inner limiting membrane in rat retina

Shaun L. Cloherty
, Raymond C. S. Wong
, Alex E. Hadjinicolaou
, Hamish Meffin
, Michael R. Ibbotson
, Brendan J. O'Brien

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

6 Citations (Scopus)

Abstract

In this paper we aim to quantify the effect of the inner limiting membrane (ILM) of the retina on the thresholds for epiretinal electrical stimulation of retinal ganglion cells by a microelectronic retinal prosthesis. A pair of bipolar stimulating electrodes was placed either above (on the epiretinal surface) or below the ILM while we made whole-cell patch-clamp recordings from retinal ganglion cells in an isolated rat retinal whole-mount preparation. Across our cell population we found no significant difference in the median threshold stimulus amplitudes when the stimulating electrodes were placed below as opposed to above the ILM (p= 0.08). However, threshold stimulus amplitudes did tend to be lower when the stimulating electrodes were placed below the ILM (30 μA vs 56 μA).

Original language	English
Title of host publication	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	2989-2992
Number of pages	4
ISBN (Print)	9781457717871
DOIs	https://doi.org/10.1109/EMBC.2012.6346592
Publication status	Published - 2012
Externally published	Yes
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2012 - Hilton San Diego Bayfront, San Diego, United States of America Duration: 28 Aug 2012 → 1 Sept 2012 Conference number: 34th https://ieeexplore.ieee.org/xpl/conhome/6320834/proceeding (Proceedings)

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2012
Abbreviated title	EMBC 2012
Country/Territory	United States of America
City	San Diego
Period	28/08/12 → 1/09/12
Internet address	https://ieeexplore.ieee.org/xpl/conhome/6320834/proceeding (Proceedings)

Access to Document

10.1109/EMBC.2012.6346592

Cite this

Cloherty, S. L., Wong, R. C. S., Hadjinicolaou, A. E., Meffin, H., Ibbotson, M. R., & O'Brien, B. J. (2012). Epiretinal electrical stimulation and the inner limiting membrane in rat retina. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 2989-2992). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2012.6346592

@inproceedings{e64bc5904b274f8a8ab76c079cd27324,

title = "Epiretinal electrical stimulation and the inner limiting membrane in rat retina",

abstract = "In this paper we aim to quantify the effect of the inner limiting membrane (ILM) of the retina on the thresholds for epiretinal electrical stimulation of retinal ganglion cells by a microelectronic retinal prosthesis. A pair of bipolar stimulating electrodes was placed either above (on the epiretinal surface) or below the ILM while we made whole-cell patch-clamp recordings from retinal ganglion cells in an isolated rat retinal whole-mount preparation. Across our cell population we found no significant difference in the median threshold stimulus amplitudes when the stimulating electrodes were placed below as opposed to above the ILM (p= 0.08). However, threshold stimulus amplitudes did tend to be lower when the stimulating electrodes were placed below the ILM (30 μA vs 56 μA).",

author = "Cloherty, \{Shaun L.\} and Wong, \{Raymond C. S.\} and Hadjinicolaou, \{Alex E.\} and Hamish Meffin and Ibbotson, \{Michael R.\} and O'Brien, \{Brendan J.\}",

year = "2012",

doi = "10.1109/EMBC.2012.6346592",

language = "English",

isbn = "9781457717871",

pages = "2989--2992",

booktitle = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States of America",

note = "International Conference of the IEEE Engineering in Medicine and Biology Society 2012, EMBC 2012 ; Conference date: 28-08-2012 Through 01-09-2012",

url = "https://ieeexplore.ieee.org/xpl/conhome/6320834/proceeding",

}

Cloherty, SL, Wong, RCS, Hadjinicolaou, AE, Meffin, H, Ibbotson, MR & O'Brien, BJ 2012, Epiretinal electrical stimulation and the inner limiting membrane in rat retina. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. IEEE, Institute of Electrical and Electronics Engineers, pp. 2989-2992, International Conference of the IEEE Engineering in Medicine and Biology Society 2012, San Diego, California, United States of America, 28/08/12. https://doi.org/10.1109/EMBC.2012.6346592

Epiretinal electrical stimulation and the inner limiting membrane in rat retina. / Cloherty, Shaun L.; Wong, Raymond C. S.; Hadjinicolaou, Alex E. et al.
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. IEEE, Institute of Electrical and Electronics Engineers, 2012. p. 2989-2992.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Epiretinal electrical stimulation and the inner limiting membrane in rat retina

AU - Cloherty, Shaun L.

AU - Wong, Raymond C. S.

AU - Hadjinicolaou, Alex E.

AU - Meffin, Hamish

AU - Ibbotson, Michael R.

AU - O'Brien, Brendan J.

N1 - Conference code: 34th

PY - 2012

Y1 - 2012

N2 - In this paper we aim to quantify the effect of the inner limiting membrane (ILM) of the retina on the thresholds for epiretinal electrical stimulation of retinal ganglion cells by a microelectronic retinal prosthesis. A pair of bipolar stimulating electrodes was placed either above (on the epiretinal surface) or below the ILM while we made whole-cell patch-clamp recordings from retinal ganglion cells in an isolated rat retinal whole-mount preparation. Across our cell population we found no significant difference in the median threshold stimulus amplitudes when the stimulating electrodes were placed below as opposed to above the ILM (p= 0.08). However, threshold stimulus amplitudes did tend to be lower when the stimulating electrodes were placed below the ILM (30 μA vs 56 μA).

AB - In this paper we aim to quantify the effect of the inner limiting membrane (ILM) of the retina on the thresholds for epiretinal electrical stimulation of retinal ganglion cells by a microelectronic retinal prosthesis. A pair of bipolar stimulating electrodes was placed either above (on the epiretinal surface) or below the ILM while we made whole-cell patch-clamp recordings from retinal ganglion cells in an isolated rat retinal whole-mount preparation. Across our cell population we found no significant difference in the median threshold stimulus amplitudes when the stimulating electrodes were placed below as opposed to above the ILM (p= 0.08). However, threshold stimulus amplitudes did tend to be lower when the stimulating electrodes were placed below the ILM (30 μA vs 56 μA).

U2 - 10.1109/EMBC.2012.6346592

DO - 10.1109/EMBC.2012.6346592

M3 - Conference Paper

SN - 9781457717871

SP - 2989

EP - 2992

BT - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

PB - IEEE, Institute of Electrical and Electronics Engineers

T2 - International Conference of the IEEE Engineering in Medicine and Biology Society 2012

Y2 - 28 August 2012 through 1 September 2012

ER -

Cloherty SL, Wong RCS, Hadjinicolaou AE, Meffin H, Ibbotson MR, O'Brien BJ. Epiretinal electrical stimulation and the inner limiting membrane in rat retina. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. IEEE, Institute of Electrical and Electronics Engineers. 2012. p. 2989-2992 doi: 10.1109/EMBC.2012.6346592