Epiretinal electrical stimulation and the inner limiting membrane in rat retina

Shaun L. Cloherty, Raymond C. S. Wong, Alex E. Hadjinicolaou, Hamish Meffin, Michael R. Ibbotson, Brendan J. O'Brien

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

6 Citations (Scopus)

Abstract

In this paper we aim to quantify the effect of the inner limiting membrane (ILM) of the retina on the thresholds for epiretinal electrical stimulation of retinal ganglion cells by a microelectronic retinal prosthesis. A pair of bipolar stimulating electrodes was placed either above (on the epiretinal surface) or below the ILM while we made whole-cell patch-clamp recordings from retinal ganglion cells in an isolated rat retinal whole-mount preparation. Across our cell population we found no significant difference in the median threshold stimulus amplitudes when the stimulating electrodes were placed below as opposed to above the ILM (p= 0.08). However, threshold stimulus amplitudes did tend to be lower when the stimulating electrodes were placed below the ILM (30 μA vs 56 μA).
Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages2989-2992
Number of pages4
ISBN (Print)9781457717871
DOIs
Publication statusPublished - 2012
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2012 - Hilton San Diego Bayfront, San Diego, United States of America
Duration: 28 Aug 20121 Sep 2012
Conference number: 34th
https://ieeexplore.ieee.org/xpl/conhome/6320834/proceeding (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2012
Abbreviated titleEMBC 2012
CountryUnited States of America
CitySan Diego
Period28/08/121/09/12
Internet address

Cite this