Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System

Isabell Kiral-Kornek, Subhrajit Roy, Ewan Nurse, Benjamin Mashford, Philippa Karoly, Thomas Carroll, Daniel Payne, Susmita Saha, Steven Baldassano, Terence O'Brien, David Grayden, Mark Cook, Dean Freestone, Stefan Harrer

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)


Background: Seizure prediction can increase independence and allow preventative treatment for patients with epilepsy. We present a proof-of-concept for a seizure prediction system that is accurate, fully automated, patient-specific, and tunable to an individual's needs. Methods: Intracranial electroencephalography (iEEG) data of ten patients obtained from a seizure advisory system were analyzed as part of a pseudoprospective seizure prediction study. First, a deep learning classifier was trained to distinguish between preictal and interictal signals. Second, classifier performance was tested on held-out iEEG data from all patients and benchmarked against the performance of a random predictor. Third, the prediction system was tuned so sensitivity or time in warning could be prioritized by the patient. Finally, a demonstration of the feasibility of deployment of the prediction system onto an ultra-low power neuromorphic chip for autonomous operation on a wearable device is provided. Results: The prediction system achieved mean sensitivity of 69% and mean time in warning of 27%, significantly surpassing an equivalent random predictor for all patients by 42%. Conclusion: This study demonstrates that deep learning in combination with neuromorphic hardware can provide the basis for a wearable, real-time, always-on, patient-specific seizure warning system with low power consumption and reliable long-term performance.

Original languageEnglish
Pages (from-to)103-111
Number of pages9
Publication statusPublished - Jan 2018
Externally publishedYes


  • Artificial intelligence
  • Deep neural networks
  • Epilepsy
  • Mobile medical devices
  • Precision medicine
  • Seizure prediction

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