Epigenetics of Diabetic Nephropathy: From Biology to Therapeutics

Keith Al-Hasani, Ishant Khurana, Theresa Farhat, Assaad Eid, Assam El-Osta

Research output: Contribution to journalReview ArticleResearchpeer-review


Diabetic nephropathy (DN) is a lethal microvascular complication associated with Type 1 and Type 2 diabetes mellitus, and is the leading single cause of end-stage renal disease. Although genetic influences are important, epigenetic mechanisms have been implicated in several aspects of the disease. The current therapeutic methods to treat DN are limited to slowing disease progression without repair and regeneration of the damaged nephrons. Replacing dying or diseased kidney cells with new nephrons is an attractive strategy. This review considers the genetic and epigenetic control of nephrogenesis, together with the epigenetic mechanisms that accompany kidney development and recent advances in induced reprogramming and kidney cell regeneration in the context of DN.
Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalEuropean Medical Journal
Issue number1
Publication statusPublished - Mar 2020

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