Epigenetics, cardiovascular disease, and cellular reprogramming

Keith Al-Hasani, Prabhu Mathiyalagan, Assam El-Osta

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Under the seeming disorder of “junk” sequences the last decade has seen developments in our understanding of non-coding RNA's (ncRNAs). It's a complex revised order and nowhere is this more relevant than in the developing heart whereby old rules have been set aside to make room for new ones. The development of the mammalian heart has been studied at the genetic and cellular level for several decades because these areas were considered ideal control points. As such, detailed mechanisms governing cell lineages are well described. Emerging evidence suggests a complex new order regulated by epigenetic mechanisms mark cardiac cell lineage. Indeed, molecular cardiologists are in the process of shedding light on the roles played by ncRNAs, nucleic acid methylation and histone/chromatin modifications in specific pathologies of the heart. The aim of this article is to discuss some of the recent advances in the field of cardiovascular epigenetics that are related to direct cell reprogramming and repair. As such, we explore ncRNAs as nodes regulating signaling networks and attempt to make sense of regulatory disorder by reinforcing the importance of epigenetic components in the developmental program.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalJournal of Molecular and Cellular Cardiology
Volume128
DOIs
Publication statusPublished - 1 Mar 2019

Cite this

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abstract = "Under the seeming disorder of “junk” sequences the last decade has seen developments in our understanding of non-coding RNA's (ncRNAs). It's a complex revised order and nowhere is this more relevant than in the developing heart whereby old rules have been set aside to make room for new ones. The development of the mammalian heart has been studied at the genetic and cellular level for several decades because these areas were considered ideal control points. As such, detailed mechanisms governing cell lineages are well described. Emerging evidence suggests a complex new order regulated by epigenetic mechanisms mark cardiac cell lineage. Indeed, molecular cardiologists are in the process of shedding light on the roles played by ncRNAs, nucleic acid methylation and histone/chromatin modifications in specific pathologies of the heart. The aim of this article is to discuss some of the recent advances in the field of cardiovascular epigenetics that are related to direct cell reprogramming and repair. As such, we explore ncRNAs as nodes regulating signaling networks and attempt to make sense of regulatory disorder by reinforcing the importance of epigenetic components in the developmental program.",
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Epigenetics, cardiovascular disease, and cellular reprogramming. / Al-Hasani, Keith; Mathiyalagan, Prabhu; El-Osta, Assam.

In: Journal of Molecular and Cellular Cardiology, Vol. 128, 01.03.2019, p. 129-133.

Research output: Contribution to journalReview ArticleResearchpeer-review

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