Epigenetics and migraine

S. H. Gan; M. M. Shaik

doi:10.1016/B978-0-12-800226-1.00011-3

Epigenetics and migraine

S. H. Gan, M. M. Shaik

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

5 Citations (Scopus)

Abstract

Migraine is a neurological disorder that manifests as a debilitating headache associated with an altered sensory perception. It has classically been attributed to multifactorial etiologies, with genetic components and environmental interactions considered to be major influences. The neuropeptide calcitonin gene-related peptide (CGRP), flavoenzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), and estrogen play key roles in migraine. In addition, receptor activity modifying protein 1 (RAMP1) is the primary receptor subunit of CGRP and plays a critical role in migraine. However, variations in the RAMP1 gene have not been found to be associated with migraine. Nevertheless, vitamins B₆, B₉, and B₁₂ and MTHFR play vital roles in both methionine biosynthesis and DNA methylation. Higher levels of homocysteine are attributed to lower levels of estrogen among migraine patients. This chapter elucidates the genetic and epigenetic roles of CGRP, MTHFR, and estrogen in the pathophysiology of migraine.

Original language	English
Title of host publication	Neuropsychiatric Disorders and Epigenetics
Editors	Dag H Yasui, Jacob Peedicayil, Dennis R Grayson
Place of Publication	London UK
Publisher	Elsevier
Chapter	11
Pages	215-231
Number of pages	17
ISBN (Print)	9780128002261
DOIs	https://doi.org/10.1016/B978-0-12-800226-1.00011-3
Publication status	Published - 2017
Externally published	Yes

Keywords

Calcitonin
CGRP
Epigenetics
Estrogen
Homocysteine
Migraine
MTHFR

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10.1016/B978-0-12-800226-1.00011-3

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title = "Epigenetics and migraine",

abstract = "Migraine is a neurological disorder that manifests as a debilitating headache associated with an altered sensory perception. It has classically been attributed to multifactorial etiologies, with genetic components and environmental interactions considered to be major influences. The neuropeptide calcitonin gene-related peptide (CGRP), flavoenzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), and estrogen play key roles in migraine. In addition, receptor activity modifying protein 1 (RAMP1) is the primary receptor subunit of CGRP and plays a critical role in migraine. However, variations in the RAMP1 gene have not been found to be associated with migraine. Nevertheless, vitamins B6, B9, and B12 and MTHFR play vital roles in both methionine biosynthesis and DNA methylation. Higher levels of homocysteine are attributed to lower levels of estrogen among migraine patients. This chapter elucidates the genetic and epigenetic roles of CGRP, MTHFR, and estrogen in the pathophysiology of migraine.",

keywords = "Calcitonin, CGRP, Epigenetics, Estrogen, Homocysteine, Migraine, MTHFR",

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AU - Gan, S. H.

AU - Shaik, M. M.

PY - 2017

Y1 - 2017

N2 - Migraine is a neurological disorder that manifests as a debilitating headache associated with an altered sensory perception. It has classically been attributed to multifactorial etiologies, with genetic components and environmental interactions considered to be major influences. The neuropeptide calcitonin gene-related peptide (CGRP), flavoenzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), and estrogen play key roles in migraine. In addition, receptor activity modifying protein 1 (RAMP1) is the primary receptor subunit of CGRP and plays a critical role in migraine. However, variations in the RAMP1 gene have not been found to be associated with migraine. Nevertheless, vitamins B6, B9, and B12 and MTHFR play vital roles in both methionine biosynthesis and DNA methylation. Higher levels of homocysteine are attributed to lower levels of estrogen among migraine patients. This chapter elucidates the genetic and epigenetic roles of CGRP, MTHFR, and estrogen in the pathophysiology of migraine.

AB - Migraine is a neurological disorder that manifests as a debilitating headache associated with an altered sensory perception. It has classically been attributed to multifactorial etiologies, with genetic components and environmental interactions considered to be major influences. The neuropeptide calcitonin gene-related peptide (CGRP), flavoenzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), and estrogen play key roles in migraine. In addition, receptor activity modifying protein 1 (RAMP1) is the primary receptor subunit of CGRP and plays a critical role in migraine. However, variations in the RAMP1 gene have not been found to be associated with migraine. Nevertheless, vitamins B6, B9, and B12 and MTHFR play vital roles in both methionine biosynthesis and DNA methylation. Higher levels of homocysteine are attributed to lower levels of estrogen among migraine patients. This chapter elucidates the genetic and epigenetic roles of CGRP, MTHFR, and estrogen in the pathophysiology of migraine.

KW - Calcitonin

KW - CGRP

KW - Epigenetics

KW - Estrogen

KW - Homocysteine

KW - Migraine

KW - MTHFR

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U2 - 10.1016/B978-0-12-800226-1.00011-3

DO - 10.1016/B978-0-12-800226-1.00011-3

M3 - Chapter (Book)

AN - SCOPUS:85010005939

SN - 9780128002261

SP - 215

EP - 231

BT - Neuropsychiatric Disorders and Epigenetics

A2 - Yasui, Dag H

A2 - Peedicayil, Jacob

A2 - Grayson, Dennis R

PB - Elsevier

CY - London UK

ER -

Epigenetics and migraine

Abstract

Keywords

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