Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a

Shunsuke Kuroki; Shogo Matoba; Mika Akiyoshi; Yasuko Matsumura; Hitoshi Miyachi; Nathan Mise; Kuniya Abe; Atsuo Ogura; Dagmar Wilhelm; Peter Anthony Koopman; Masami Nozaki; Yoshiakira Kanai; Yoichi Shinkai; Makoto Tachibana

doi:10.1126/science.1239864

Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a

Shunsuke Kuroki, Shogo Matoba, Mika Akiyoshi, Yasuko Matsumura, Hitoshi Miyachi, Nathan Mise, Kuniya Abe, Atsuo Ogura, Dagmar Wilhelm, Peter Anthony Koopman, Masami Nozaki, Yoshiakira Kanai, Yoichi Shinkai, Makoto Tachibana

Anatomy & Developmental Biology

Research output: Contribution to journal › Article › Research › peer-review

231 Citations (Scopus)

Abstract

Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.

Original language	English
Pages (from-to)	1106 - 1109
Number of pages	4
Journal	Science
Volume	341
Issue number	6150
DOIs	https://doi.org/10.1126/science.1239864
Publication status	Published - 2013

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title = "Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a",

abstract = "Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.",

author = "Shunsuke Kuroki and Shogo Matoba and Mika Akiyoshi and Yasuko Matsumura and Hitoshi Miyachi and Nathan Mise and Kuniya Abe and Atsuo Ogura and Dagmar Wilhelm and Koopman, \{Peter Anthony\} and Masami Nozaki and Yoshiakira Kanai and Yoichi Shinkai and Makoto Tachibana",

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doi = "10.1126/science.1239864",

language = "English",

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TY - JOUR

T1 - Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a

AU - Kuroki, Shunsuke

AU - Matoba, Shogo

AU - Akiyoshi, Mika

AU - Matsumura, Yasuko

AU - Miyachi, Hitoshi

AU - Mise, Nathan

AU - Abe, Kuniya

AU - Ogura, Atsuo

AU - Wilhelm, Dagmar

AU - Koopman, Peter Anthony

AU - Nozaki, Masami

AU - Kanai, Yoshiakira

AU - Shinkai, Yoichi

AU - Tachibana, Makoto

PY - 2013

Y1 - 2013

N2 - Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.

AB - Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.

UR - http://www.sciencemag.org/content/341/6150/1106.full.pdf

UR - https://www.scopus.com/pages/publications/84883466759

U2 - 10.1126/science.1239864

DO - 10.1126/science.1239864

M3 - Article

SN - 0036-8075

VL - 341

SP - 1106

EP - 1109

JO - Science

JF - Science

IS - 6150

ER -

Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a

Abstract

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