Epigenetic phenomena linked to diabetic complications

Luciano Pirola, Aneta Balcerczyk, Jun Okabe, Assam El-Osta

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Diabetes mellitus (type 1 and type 2) and the complications associated with this condition are an urgent public health problem, as the incidence of diabetes mellitus is steadily increasing. Environmental factors, such as diet and exposure to hyperglycemia, contribute to the etiology of diabetes mellitus and its associated microvascular and macrovascular complications. These vascular complications are the main cause of the morbidity and mortality burden of diabetes mellitus. The DCCT-EDIC and UKPDS epidemiological studies correlated poor glycemic control with the development of vascular complications in patients with type 1 or type 2 diabetes mellitus. The findings of these studies suggest that early exposure to hyperglycemia predisposes individuals to the development of diabetic complications, a phenomenon referred to as metabolic memory or the legacy effect. The first experimental evidence for metabolic memory was reported >20 years ago and the underlying molecular mechanisms are currently being characterized. Interestingly, transient exposure to hyperglycemia results in long-lasting epigenetic modifications that lead to changes in chromatin structure and gene expression, which mediate these persistent metabolic characteristics.

Original languageEnglish
Pages (from-to)665-675
Number of pages11
JournalNature Reviews Endocrinology
Volume6
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Cite this

Pirola, Luciano ; Balcerczyk, Aneta ; Okabe, Jun ; El-Osta, Assam. / Epigenetic phenomena linked to diabetic complications. In: Nature Reviews Endocrinology. 2010 ; Vol. 6, No. 12. pp. 665-675.
@article{23b9ab274c5849c9ab5fee3242f606f3,
title = "Epigenetic phenomena linked to diabetic complications",
abstract = "Diabetes mellitus (type 1 and type 2) and the complications associated with this condition are an urgent public health problem, as the incidence of diabetes mellitus is steadily increasing. Environmental factors, such as diet and exposure to hyperglycemia, contribute to the etiology of diabetes mellitus and its associated microvascular and macrovascular complications. These vascular complications are the main cause of the morbidity and mortality burden of diabetes mellitus. The DCCT-EDIC and UKPDS epidemiological studies correlated poor glycemic control with the development of vascular complications in patients with type 1 or type 2 diabetes mellitus. The findings of these studies suggest that early exposure to hyperglycemia predisposes individuals to the development of diabetic complications, a phenomenon referred to as metabolic memory or the legacy effect. The first experimental evidence for metabolic memory was reported >20 years ago and the underlying molecular mechanisms are currently being characterized. Interestingly, transient exposure to hyperglycemia results in long-lasting epigenetic modifications that lead to changes in chromatin structure and gene expression, which mediate these persistent metabolic characteristics.",
author = "Luciano Pirola and Aneta Balcerczyk and Jun Okabe and Assam El-Osta",
year = "2010",
month = "12",
doi = "10.1038/nrendo.2010.188",
language = "English",
volume = "6",
pages = "665--675",
journal = "Nature Reviews Endocrinology",
issn = "1759-5029",
publisher = "Nature Publishing Group",
number = "12",

}

Epigenetic phenomena linked to diabetic complications. / Pirola, Luciano; Balcerczyk, Aneta; Okabe, Jun; El-Osta, Assam.

In: Nature Reviews Endocrinology, Vol. 6, No. 12, 12.2010, p. 665-675.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Epigenetic phenomena linked to diabetic complications

AU - Pirola, Luciano

AU - Balcerczyk, Aneta

AU - Okabe, Jun

AU - El-Osta, Assam

PY - 2010/12

Y1 - 2010/12

N2 - Diabetes mellitus (type 1 and type 2) and the complications associated with this condition are an urgent public health problem, as the incidence of diabetes mellitus is steadily increasing. Environmental factors, such as diet and exposure to hyperglycemia, contribute to the etiology of diabetes mellitus and its associated microvascular and macrovascular complications. These vascular complications are the main cause of the morbidity and mortality burden of diabetes mellitus. The DCCT-EDIC and UKPDS epidemiological studies correlated poor glycemic control with the development of vascular complications in patients with type 1 or type 2 diabetes mellitus. The findings of these studies suggest that early exposure to hyperglycemia predisposes individuals to the development of diabetic complications, a phenomenon referred to as metabolic memory or the legacy effect. The first experimental evidence for metabolic memory was reported >20 years ago and the underlying molecular mechanisms are currently being characterized. Interestingly, transient exposure to hyperglycemia results in long-lasting epigenetic modifications that lead to changes in chromatin structure and gene expression, which mediate these persistent metabolic characteristics.

AB - Diabetes mellitus (type 1 and type 2) and the complications associated with this condition are an urgent public health problem, as the incidence of diabetes mellitus is steadily increasing. Environmental factors, such as diet and exposure to hyperglycemia, contribute to the etiology of diabetes mellitus and its associated microvascular and macrovascular complications. These vascular complications are the main cause of the morbidity and mortality burden of diabetes mellitus. The DCCT-EDIC and UKPDS epidemiological studies correlated poor glycemic control with the development of vascular complications in patients with type 1 or type 2 diabetes mellitus. The findings of these studies suggest that early exposure to hyperglycemia predisposes individuals to the development of diabetic complications, a phenomenon referred to as metabolic memory or the legacy effect. The first experimental evidence for metabolic memory was reported >20 years ago and the underlying molecular mechanisms are currently being characterized. Interestingly, transient exposure to hyperglycemia results in long-lasting epigenetic modifications that lead to changes in chromatin structure and gene expression, which mediate these persistent metabolic characteristics.

UR - http://www.scopus.com/inward/record.url?scp=78649449258&partnerID=8YFLogxK

U2 - 10.1038/nrendo.2010.188

DO - 10.1038/nrendo.2010.188

M3 - Review Article

VL - 6

SP - 665

EP - 675

JO - Nature Reviews Endocrinology

JF - Nature Reviews Endocrinology

SN - 1759-5029

IS - 12

ER -