Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: evidence and implications

Jaber Firas, Ethan X Liu, Jose M Polo

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Six decades ago, seminal work conducted by John Gurdon on genome conservation resulted in major advancements towards nuclear reprogramming technologies such as somatic cell nuclear transfer (SCNT), cell fusion and transcription factor mediated reprogramming. This revolutionized our views regarding cell fate conversion and development. These technologies also shed light on the role of the epigenome in cellular identity, and how the memory of the cell of origin affects the reprogrammed cell. This review will discuss recent work on epigenetic memory retained in pluripotent cells derived by SCNT and transcription factor mediated reprogramming, and the challenges attached to it.
Original languageEnglish
Pages (from-to)29 - 32
Number of pages4
JournalDifferentiation
Volume88
Issue number1
DOIs
Publication statusPublished - 2014

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