Epigenetic basis of disease

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Abstract

Epigenetics refers to the inheritance of information contained outside the underlying DNA sequence. Post translational epigenetic modifications including DNA methylation, histone modifications and chromatin remodelling are epigenetically inherited. Epigenetic processes enable organisms to repress various gene sets depending on the cell type and are passed from mother to
daughter cells allowing the maintenance of cell identity. Misregulation of epigenetic processes can cause silencing or ectopic expression of genes and this often leads to disease states. Typically the hallmarks of malignancy are genomic rearrangements and gross morphologies. However, epigenetic misregulation is also typically observed in malignant cells - for example, DNA hypermethylation causing promoter silencing of tumor suppressor genes. Genomics, proteomics, metabolomics and transcriptomics are emerging technologies that are part of the 'Omics' umbrella or high throughput technologies. These are now routinely used in cancer research allowing researchers to determine differences in normal compared to disease states. Ultimately, the premise is that these will improve the screening, diagnosis and treatments of cancers. These emerging technologies, which are considered in this chapter, serve as potential tools in early detection of cancers and for identifying biomarkers for high risk individuals.
Original languageEnglish
Title of host publicationEpigenomic Medicine
EditorsTom C Karagiannis
Place of PublicationKerala, India
PublisherTransworld Research Network
Pages31-43
Number of pages13
ISBN (Print)9788178955292
Publication statusPublished - 2011

Cite this

Venables, G., Tuano, N. K., El-Osta, A., & Karagiannis, T. C. (2011). Epigenetic basis of disease. In T. C. Karagiannis (Ed.), Epigenomic Medicine (pp. 31-43). Kerala, India: Transworld Research Network.
Venables, Gene ; Tuano, Natasha K. ; El-Osta, Assam ; Karagiannis, Tom C. / Epigenetic basis of disease. Epigenomic Medicine. editor / Tom C Karagiannis . Kerala, India : Transworld Research Network, 2011. pp. 31-43
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abstract = "Epigenetics refers to the inheritance of information contained outside the underlying DNA sequence. Post translational epigenetic modifications including DNA methylation, histone modifications and chromatin remodelling are epigenetically inherited. Epigenetic processes enable organisms to repress various gene sets depending on the cell type and are passed from mother todaughter cells allowing the maintenance of cell identity. Misregulation of epigenetic processes can cause silencing or ectopic expression of genes and this often leads to disease states. Typically the hallmarks of malignancy are genomic rearrangements and gross morphologies. However, epigenetic misregulation is also typically observed in malignant cells - for example, DNA hypermethylation causing promoter silencing of tumor suppressor genes. Genomics, proteomics, metabolomics and transcriptomics are emerging technologies that are part of the 'Omics' umbrella or high throughput technologies. These are now routinely used in cancer research allowing researchers to determine differences in normal compared to disease states. Ultimately, the premise is that these will improve the screening, diagnosis and treatments of cancers. These emerging technologies, which are considered in this chapter, serve as potential tools in early detection of cancers and for identifying biomarkers for high risk individuals.",
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Venables, G, Tuano, NK, El-Osta, A & Karagiannis, TC 2011, Epigenetic basis of disease. in TC Karagiannis (ed.), Epigenomic Medicine. Transworld Research Network, Kerala, India, pp. 31-43.

Epigenetic basis of disease. / Venables, Gene; Tuano, Natasha K.; El-Osta, Assam; Karagiannis, Tom C.

Epigenomic Medicine. ed. / Tom C Karagiannis . Kerala, India : Transworld Research Network, 2011. p. 31-43.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

TY - CHAP

T1 - Epigenetic basis of disease

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AU - Tuano, Natasha K.

AU - El-Osta, Assam

AU - Karagiannis, Tom C

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N2 - Epigenetics refers to the inheritance of information contained outside the underlying DNA sequence. Post translational epigenetic modifications including DNA methylation, histone modifications and chromatin remodelling are epigenetically inherited. Epigenetic processes enable organisms to repress various gene sets depending on the cell type and are passed from mother todaughter cells allowing the maintenance of cell identity. Misregulation of epigenetic processes can cause silencing or ectopic expression of genes and this often leads to disease states. Typically the hallmarks of malignancy are genomic rearrangements and gross morphologies. However, epigenetic misregulation is also typically observed in malignant cells - for example, DNA hypermethylation causing promoter silencing of tumor suppressor genes. Genomics, proteomics, metabolomics and transcriptomics are emerging technologies that are part of the 'Omics' umbrella or high throughput technologies. These are now routinely used in cancer research allowing researchers to determine differences in normal compared to disease states. Ultimately, the premise is that these will improve the screening, diagnosis and treatments of cancers. These emerging technologies, which are considered in this chapter, serve as potential tools in early detection of cancers and for identifying biomarkers for high risk individuals.

AB - Epigenetics refers to the inheritance of information contained outside the underlying DNA sequence. Post translational epigenetic modifications including DNA methylation, histone modifications and chromatin remodelling are epigenetically inherited. Epigenetic processes enable organisms to repress various gene sets depending on the cell type and are passed from mother todaughter cells allowing the maintenance of cell identity. Misregulation of epigenetic processes can cause silencing or ectopic expression of genes and this often leads to disease states. Typically the hallmarks of malignancy are genomic rearrangements and gross morphologies. However, epigenetic misregulation is also typically observed in malignant cells - for example, DNA hypermethylation causing promoter silencing of tumor suppressor genes. Genomics, proteomics, metabolomics and transcriptomics are emerging technologies that are part of the 'Omics' umbrella or high throughput technologies. These are now routinely used in cancer research allowing researchers to determine differences in normal compared to disease states. Ultimately, the premise is that these will improve the screening, diagnosis and treatments of cancers. These emerging technologies, which are considered in this chapter, serve as potential tools in early detection of cancers and for identifying biomarkers for high risk individuals.

M3 - Chapter (Book)

SN - 9788178955292

SP - 31

EP - 43

BT - Epigenomic Medicine

A2 - Karagiannis , Tom C

PB - Transworld Research Network

CY - Kerala, India

ER -

Venables G, Tuano NK, El-Osta A, Karagiannis TC. Epigenetic basis of disease. In Karagiannis TC, editor, Epigenomic Medicine. Kerala, India: Transworld Research Network. 2011. p. 31-43