Observational and clinical trial data have accrued to show that acute/chronic heart disease can directly contribute to
and/or accelerate acute/chronic worsening kidney function
and vice versa. A description of the epidemiology of
heart?kidney interaction, as defined by the proposed consensus
cardio-renal syndrome (CRS) definitions, is a critical
initial step towards understanding not only the overall
burden of disease for each of the proposed CRS subtypes,
but also their natural history, associated morbidity and
mortality and potential health resource implications .
Importantly, these CRS subtypes may have important discriminating
features in terms of predisposing or precipitating
events, risk identification, natural history and outcomes.
Likewise, a surveillance of the epidemiology is vital for determining
whether there exist important gaps in knowledge
and for the design of future epidemiologic investigations
and clinical trials. Accordingly, this article will summarize
the epidemiology of CRS.