TY - JOUR
T1 - Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam
AU - Anders, Katherine
AU - Nguyen, Hoa L
AU - Nguyen, Nguyet Minh
AU - Van Thuy, Nguyen Thi
AU - Nguyen, Thi Hong Van
AU - Nguyen, Trong Hieu
AU - Nguyen, Thi Hong Tham
AU - Ha, Phan Thi
AU - Le, Bich Lien
AU - Chau, Nguyen Van Vinh
AU - Hang, Vu Thi Ty
AU - van Doorn, H Rogier
AU - Simmons, Cameron P
PY - 2015
Y1 - 2015
N2 - Background: Understanding viral etiology and age-specific incidence of acute respiratory infections in infants can help identify risk groups and inform vaccine delivery, but community-based data is lacking from tropical settings. Methods: One thousand four hundred and seventy-eight infants in urban Ho Chi Minh City and 981 infants in a semi-rural district in southern Vietnam were enrolled at birth and followed to 1 year of age. Acute respiratory infection (ARI) episodes were identified through clinic-based illness surveillance, hospital admissions and self-reports. Nasopharyngeal swabs were collected from infants with respiratory symptoms and tested for 14 respiratory pathogens using multiplex reverse transcription-polymerase chain reaction. Results: Estimated incidence of ARI was 542 and 2691 per 1000 infant-years, and hospitalization rates for ARI were 81 and 138 per 1000 infant-years, in urban and semi-rural cohorts, respectively, from clinic- and hospital-based surveillance. However self-reported ARI episodes were just 1.5-fold higher in the semi-rural versus urban cohort, indicating that part of the urban-rural difference was explained by under-ascertainment in the urban cohort. Incidence was higher in infants =6 months of age than
AB - Background: Understanding viral etiology and age-specific incidence of acute respiratory infections in infants can help identify risk groups and inform vaccine delivery, but community-based data is lacking from tropical settings. Methods: One thousand four hundred and seventy-eight infants in urban Ho Chi Minh City and 981 infants in a semi-rural district in southern Vietnam were enrolled at birth and followed to 1 year of age. Acute respiratory infection (ARI) episodes were identified through clinic-based illness surveillance, hospital admissions and self-reports. Nasopharyngeal swabs were collected from infants with respiratory symptoms and tested for 14 respiratory pathogens using multiplex reverse transcription-polymerase chain reaction. Results: Estimated incidence of ARI was 542 and 2691 per 1000 infant-years, and hospitalization rates for ARI were 81 and 138 per 1000 infant-years, in urban and semi-rural cohorts, respectively, from clinic- and hospital-based surveillance. However self-reported ARI episodes were just 1.5-fold higher in the semi-rural versus urban cohort, indicating that part of the urban-rural difference was explained by under-ascertainment in the urban cohort. Incidence was higher in infants =6 months of age than
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418783/pdf/inf-34-361.pdf
U2 - 10.1097/INF.0000000000000643
DO - 10.1097/INF.0000000000000643
M3 - Article
SN - 0891-3668
VL - 34
SP - 361
EP - 370
JO - The Pediatric Infectious Disease Journal
JF - The Pediatric Infectious Disease Journal
IS - 4
ER -
