Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam

Duong Le Quyen, Nguyen Thanh Le, Cao Thi Van Anh, Nguyen Binh Nguyen, Dong Van Hoang, Jacqui L. Montgomery, Simon C. Kutcher, Nguyen Hoang Le, Nguyen Tran Hien, Duong Thi Hue Kien, Maia Rabaa, Scott L. O'Neill, Cameron P. Simmons, Dang Duc Anh, Katherine L. Anders

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Vietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation k = 0.47). Of 451 children aged 1-10 years enrolled in a cross-sectional serosurvey, almost one-third had evidence of a past dengue virus (DENV) infection, with older children more likely to have a multitypic response indicative of past exposure to 3 1 serotype. All four DENV serotypes were detected in hospitalized patients during 8 months of sampling in 2015. Mobility data collected from 1,000 children and young adults via prospective travel diaries showed that, although all ages spent approximately half of their daytime hours (5:00 AM-9:00 PM) at home, younger age groups (€ 14 years) spent a significantly greater proportion of their time within 500m of home than older respondents. Together these findings inform the rational design of future trials of dengue preventive interventions in this setting by identifying 1) children < 7 years as an optimal target group for a flavivirus-naive serological cohort, 2) children and young adults as the predominant patient population for a study with a clinical end point of symptomatic dengue, and 3) substantial spatial and temporal variations in DENV transmission, with a consequent requirement for a trial to be large enough and of long enough duration to overcome this heterogeneity.

Original languageEnglish
Pages (from-to)402-409
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number2
DOIs
Publication statusPublished - 2018

Cite this

Quyen, D. L., Le, N. T., Van Anh, C. T., Nguyen, N. B., Van Hoang, D., Montgomery, J. L., ... Anders, K. L. (2018). Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam. American Journal of Tropical Medicine and Hygiene, 98(2), 402-409. https://doi.org/10.4269/ajtmh.17-0630
Quyen, Duong Le ; Le, Nguyen Thanh ; Van Anh, Cao Thi ; Nguyen, Nguyen Binh ; Van Hoang, Dong ; Montgomery, Jacqui L. ; Kutcher, Simon C. ; Le, Nguyen Hoang ; Hien, Nguyen Tran ; Kien, Duong Thi Hue ; Rabaa, Maia ; O'Neill, Scott L. ; Simmons, Cameron P. ; Anh, Dang Duc ; Anders, Katherine L. / Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam. In: American Journal of Tropical Medicine and Hygiene. 2018 ; Vol. 98, No. 2. pp. 402-409.
@article{a98360e53e344d5f9dabbd940fa68794,
title = "Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam",
abstract = "Vietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation k = 0.47). Of 451 children aged 1-10 years enrolled in a cross-sectional serosurvey, almost one-third had evidence of a past dengue virus (DENV) infection, with older children more likely to have a multitypic response indicative of past exposure to 3 1 serotype. All four DENV serotypes were detected in hospitalized patients during 8 months of sampling in 2015. Mobility data collected from 1,000 children and young adults via prospective travel diaries showed that, although all ages spent approximately half of their daytime hours (5:00 AM-9:00 PM) at home, younger age groups (€ 14 years) spent a significantly greater proportion of their time within 500m of home than older respondents. Together these findings inform the rational design of future trials of dengue preventive interventions in this setting by identifying 1) children < 7 years as an optimal target group for a flavivirus-naive serological cohort, 2) children and young adults as the predominant patient population for a study with a clinical end point of symptomatic dengue, and 3) substantial spatial and temporal variations in DENV transmission, with a consequent requirement for a trial to be large enough and of long enough duration to overcome this heterogeneity.",
author = "Quyen, {Duong Le} and Le, {Nguyen Thanh} and {Van Anh}, {Cao Thi} and Nguyen, {Nguyen Binh} and {Van Hoang}, Dong and Montgomery, {Jacqui L.} and Kutcher, {Simon C.} and Le, {Nguyen Hoang} and Hien, {Nguyen Tran} and Kien, {Duong Thi Hue} and Maia Rabaa and O'Neill, {Scott L.} and Simmons, {Cameron P.} and Anh, {Dang Duc} and Anders, {Katherine L.}",
year = "2018",
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Quyen, DL, Le, NT, Van Anh, CT, Nguyen, NB, Van Hoang, D, Montgomery, JL, Kutcher, SC, Le, NH, Hien, NT, Kien, DTH, Rabaa, M, O'Neill, SL, Simmons, CP, Anh, DD & Anders, KL 2018, 'Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam' American Journal of Tropical Medicine and Hygiene, vol. 98, no. 2, pp. 402-409. https://doi.org/10.4269/ajtmh.17-0630

Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam. / Quyen, Duong Le; Le, Nguyen Thanh; Van Anh, Cao Thi; Nguyen, Nguyen Binh; Van Hoang, Dong; Montgomery, Jacqui L.; Kutcher, Simon C.; Le, Nguyen Hoang; Hien, Nguyen Tran; Kien, Duong Thi Hue; Rabaa, Maia; O'Neill, Scott L.; Simmons, Cameron P.; Anh, Dang Duc; Anders, Katherine L.

In: American Journal of Tropical Medicine and Hygiene, Vol. 98, No. 2, 2018, p. 402-409.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam

AU - Quyen, Duong Le

AU - Le, Nguyen Thanh

AU - Van Anh, Cao Thi

AU - Nguyen, Nguyen Binh

AU - Van Hoang, Dong

AU - Montgomery, Jacqui L.

AU - Kutcher, Simon C.

AU - Le, Nguyen Hoang

AU - Hien, Nguyen Tran

AU - Kien, Duong Thi Hue

AU - Rabaa, Maia

AU - O'Neill, Scott L.

AU - Simmons, Cameron P.

AU - Anh, Dang Duc

AU - Anders, Katherine L.

PY - 2018

Y1 - 2018

N2 - Vietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation k = 0.47). Of 451 children aged 1-10 years enrolled in a cross-sectional serosurvey, almost one-third had evidence of a past dengue virus (DENV) infection, with older children more likely to have a multitypic response indicative of past exposure to 3 1 serotype. All four DENV serotypes were detected in hospitalized patients during 8 months of sampling in 2015. Mobility data collected from 1,000 children and young adults via prospective travel diaries showed that, although all ages spent approximately half of their daytime hours (5:00 AM-9:00 PM) at home, younger age groups (€ 14 years) spent a significantly greater proportion of their time within 500m of home than older respondents. Together these findings inform the rational design of future trials of dengue preventive interventions in this setting by identifying 1) children < 7 years as an optimal target group for a flavivirus-naive serological cohort, 2) children and young adults as the predominant patient population for a study with a clinical end point of symptomatic dengue, and 3) substantial spatial and temporal variations in DENV transmission, with a consequent requirement for a trial to be large enough and of long enough duration to overcome this heterogeneity.

AB - Vietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation k = 0.47). Of 451 children aged 1-10 years enrolled in a cross-sectional serosurvey, almost one-third had evidence of a past dengue virus (DENV) infection, with older children more likely to have a multitypic response indicative of past exposure to 3 1 serotype. All four DENV serotypes were detected in hospitalized patients during 8 months of sampling in 2015. Mobility data collected from 1,000 children and young adults via prospective travel diaries showed that, although all ages spent approximately half of their daytime hours (5:00 AM-9:00 PM) at home, younger age groups (€ 14 years) spent a significantly greater proportion of their time within 500m of home than older respondents. Together these findings inform the rational design of future trials of dengue preventive interventions in this setting by identifying 1) children < 7 years as an optimal target group for a flavivirus-naive serological cohort, 2) children and young adults as the predominant patient population for a study with a clinical end point of symptomatic dengue, and 3) substantial spatial and temporal variations in DENV transmission, with a consequent requirement for a trial to be large enough and of long enough duration to overcome this heterogeneity.

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