EphA3 biology and cancer

Peter W Janes; Christopher I Slape; Rae H Farnsworth; Lakmali S K Atapattu Mudiyanselage; Andrew Mark Scott; Mary E Vail

doi:10.3109/08977194.2014.982276

EphA3 biology and cancer

Peter W Janes
, Christopher I Slape
, Rae H Farnsworth
, Lakmali S K Atapattu Mudiyanselage
, Andrew Mark Scott
, Mary E Vail

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

61 Citations (Scopus)

Abstract

Abstract Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.

Original language	English
Pages (from-to)	176 - 189
Number of pages	14
Journal	Growth Factors
Volume	32
Issue number	6
DOIs	https://doi.org/10.3109/08977194.2014.982276
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3109/08977194.2014.982276

Cite this

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abstract = "Abstract Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.",

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AU - Janes, Peter W

AU - Slape, Christopher I

AU - Farnsworth, Rae H

AU - Atapattu Mudiyanselage, Lakmali S K

AU - Scott, Andrew Mark

AU - Vail, Mary E

PY - 2014

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N2 - Abstract Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.

AB - Abstract Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.

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JO - Growth Factors

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EphA3 biology and cancer

Abstract

UN SDGs

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