EphA3 biology and cancer

Peter W Janes, Christopher I Slape, Rae H Farnsworth, Lakmali S K Atapattu Mudiyanselage, Andrew Mark Scott, Mary E Vail

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Abstract Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.
Original languageEnglish
Pages (from-to)176 - 189
Number of pages14
JournalGrowth Factors
Volume32
Issue number6
DOIs
Publication statusPublished - 2014

Cite this

Janes, P. W., Slape, C. I., Farnsworth, R. H., Atapattu Mudiyanselage, L. S. K., Scott, A. M., & Vail, M. E. (2014). EphA3 biology and cancer. Growth Factors, 32(6), 176 - 189. https://doi.org/10.3109/08977194.2014.982276
Janes, Peter W ; Slape, Christopher I ; Farnsworth, Rae H ; Atapattu Mudiyanselage, Lakmali S K ; Scott, Andrew Mark ; Vail, Mary E. / EphA3 biology and cancer. In: Growth Factors. 2014 ; Vol. 32, No. 6. pp. 176 - 189.
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Janes, PW, Slape, CI, Farnsworth, RH, Atapattu Mudiyanselage, LSK, Scott, AM & Vail, ME 2014, 'EphA3 biology and cancer', Growth Factors, vol. 32, no. 6, pp. 176 - 189. https://doi.org/10.3109/08977194.2014.982276

EphA3 biology and cancer. / Janes, Peter W; Slape, Christopher I; Farnsworth, Rae H; Atapattu Mudiyanselage, Lakmali S K; Scott, Andrew Mark; Vail, Mary E.

In: Growth Factors, Vol. 32, No. 6, 2014, p. 176 - 189.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Vail, Mary E

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Janes PW, Slape CI, Farnsworth RH, Atapattu Mudiyanselage LSK, Scott AM, Vail ME. EphA3 biology and cancer. Growth Factors. 2014;32(6):176 - 189. https://doi.org/10.3109/08977194.2014.982276