Enzyme Responsive Inverse Opal Hydrogels

Yi Pei, Thomas G. Molley, Kristopher A. Kilian

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Structured color in nature is controlled by nano- and micro-structured interfaces giving rise to a photonic bandgap. This study presents a biomimetic optical material based on polymeric inverse opals that respond to enzyme activity. Polymer colloids provide a template in which acryloyl-functionalized poly(ethylene glycol) is integrated; dissolution of the colloids leads to a hydrogel inverse opal that can be lithographically patterned using transfer printing. Incorporating enzyme substrates within the voids provides a material that responds to the presence of proteases through a shift in the optical properties.

Original languageEnglish
Article number1900555
Number of pages6
JournalMacromolecular Rapid Communications
Issue number5
Publication statusPublished - Mar 2020
Externally publishedYes


  • biodegradable
  • biomaterials
  • biomimetic materials
  • enzymes
  • hydrogel

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