Enzyme engineering lets us play with new building blocks in non-ribosomal peptide synthesis

Minuri S. Ratnayake, Mathias H. Hansen, Max J. Cryle

Research output: Contribution to journalComment / DebateOtherpeer-review


In a recent issue of Nature Chemical Biology, Folger et al. demonstrated a high-throughput approach for engineering peptide bond forming domains from non-ribosomal peptide synthesis. A non-ribosomal peptide synthetase module from surfactin biosynthesis was reprogrammed to accept a fatty acid substrate into peptide biosynthesis, thus illustrating the potential of this approach for generating novel bioactive peptides.

Original languageEnglish
Pages (from-to)520-522
Number of pages3
Issue number5
Publication statusPublished - 2 May 2024

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